{"id":"W2070159057","doi":"10.2337/db05-1566","title":"Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Amylin; Prohormone convertase; Amyloid (mycology); Programmed cell death; Internal medicine; Endocrinology; Amyloid precursor protein; TUNEL assay; Islet; Apoptosis; Biology; Chemistry; Cell biology; Prohormone; Alzheimer's disease; Biochemistry; Insulin; Medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002189128,0.0001919273,0.0003349296,0.0001047536,0.000158699,0.00004539233,0.00007743368,0.00005835928,0.00003287376],"category_scores_gemma":[0.00005616211,0.000133138,0.0000588014,0.000154684,0.0001038788,0.000179897,0.00003281399,0.0001082064,0.00001464014],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004176436,"about_ca_system_score_gemma":0.00004355507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009782681,"about_ca_topic_score_gemma":0.000003723658,"domain_scores_codex":[0.998799,0.00003875843,0.000373542,0.0002144602,0.0002494978,0.000324783],"domain_scores_gemma":[0.9993314,0.00006355828,0.0001633837,0.0002100972,0.0001085678,0.0001230511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004653052,0.0001662266,0.1266023,0.0004028864,0.00001170751,0.000001572835,0.0003224184,0.00000110495,0.8644736,0.00002632032,0.005786451,0.002158893],"study_design_scores_gemma":[0.001462632,0.0006352988,0.05814686,0.0001907864,0.0001474572,0.000006615219,0.0002174984,0.001085712,0.9372781,0.000110395,0.000538584,0.0001800538],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957212,0.0009685677,0.00003269953,0.0003810488,0.00002466278,0.0006909445,0.00002994063,0.00006853998,0.002082449],"genre_scores_gemma":[0.9974674,0.000004906694,0.0003353758,0.0005981679,0.00009051782,0.00009756986,0.0001576778,0.00002297722,0.001225381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07280452,"threshold_uncertainty_score":0.5429212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124014259482037,"score_gpt":0.238807425023991,"score_spread":0.2275672824291706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}