{"id":"W2070159057","doi":"10.2337/db05-1566","title":"Impaired NH2-Terminal Processing of Human Proislet Amyloid Polypeptide by the Prohormone Convertase PC2 Leads to Amyloid Formation and Cell Death","year":2006,"lang":"en","type":"article","venue":"Diabetes","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Amylin; Prohormone convertase; Amyloid (mycology); Programmed cell death; Internal medicine; Endocrinology; Amyloid precursor protein; TUNEL assay; Islet; Apoptosis; Biology; Chemistry; Cell biology; Prohormone; Alzheimer's disease; Biochemistry; Insulin; Medicine; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001908728,0.0007689796,0.0003567167,0.0001978196,0.0001342418,0.0005676256,0.0001796011,0.0003150747,0.0009140931],"category_scores_gemma":[0.0001409913,0.0001759533,0.0003262737,0.0001934989,0.0003564131,0.0002433772,0.0001917243,0.0007296876,0.000459503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003546199,"about_ca_system_score_gemma":0.0001722788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006183473,"about_ca_topic_score_gemma":0.0004932013,"domain_scores_codex":[0.9997339,0.00003297872,0.00002304289,0.00006060581,0.00007773818,0.00007180458],"domain_scores_gemma":[0.9998434,0.00002903063,0.00003505137,0.00002181671,0.00001169912,0.00005907672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004834619,0.00006992269,0.0003218985,0.00001972791,0.00001089543,0.000102831,0.00001062083,0.00003363562,0.9982628,0.00003325018,0.00002560508,0.0006253134],"study_design_scores_gemma":[0.00004673692,0.0006298488,0.008050486,0.00000407139,0.00002701589,0.0008945342,0.0000233303,0.0007576614,0.9886605,0.00003628832,0.0008646681,0.000004889877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973713,0.0009973098,0.0008519983,0.00002192679,0.00002181455,0.00001403099,0.0001482664,0.00002944972,0.0005440069],"genre_scores_gemma":[0.9960133,0.0007188279,0.001049103,0.00003549085,0.00001718256,0.00002463108,0.0006757146,0.00001658996,0.001449186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009140931,"threshold_uncertainty_score":0.003057957,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01124014259482037,"score_gpt":0.238807425023991,"score_spread":0.2275672824291706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}