{"id":"W2070164943","doi":"10.1016/j.str.2013.09.018","title":"Structural Interactions between Inhibitor and Substrate Docking Sites Give Insight into Mechanisms of Human PS1 Complexes","year":2013,"lang":"en","type":"article","venue":"Structure","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Core Research for Evolutional Science and Technology; National Institute on Aging; Japan Society for the Promotion of Science; Alzheimer Society; Canadian Institutes of Health Research; National Institutes of Health; Wellcome Trust; Medical Research Council; Wellcome","keywords":"Docking (animal); Ectodomain; Chemistry; Binding site; Active site; Biophysics; Nicastrin; Presenilin; Stereochemistry; Biochemistry; Enzyme; Biology; Medicine; Receptor; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001622559,0.0001908449,0.0001969954,0.00004370606,0.0001409528,0.00004630437,0.0001244169,0.0001653609,0.0001363311],"category_scores_gemma":[0.00001845893,0.0001517882,0.00005383504,0.00007750998,0.0001269813,0.0000230165,0.000114555,0.0001466039,0.00000105515],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009058781,"about_ca_system_score_gemma":0.00001076557,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007259039,"about_ca_topic_score_gemma":0.00005597335,"domain_scores_codex":[0.9991673,0.00003157862,0.0002512684,0.0002879592,0.00009995568,0.0001619556],"domain_scores_gemma":[0.9994748,0.000009523343,0.0001440835,0.0001667164,0.0001232874,0.00008154025],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008646363,0.000001396221,0.0088132,0.00003626809,0.00003839836,2.195715e-7,0.0002081769,0.000001263748,0.9895784,0.0004361134,0.00003536016,0.0008425315],"study_design_scores_gemma":[0.0001871363,0.0000945851,0.1199911,0.00001383146,0.00001744893,0.000008442489,0.00007184783,0.00001970766,0.8653231,0.01401426,0.00009174811,0.0001668228],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992824,0.00007803272,0.00008233981,0.0001252354,0.0001017339,0.0001696696,0.00009003725,0.00001367766,0.00005692234],"genre_scores_gemma":[0.9977667,0.000004664807,0.0007207774,0.00005859095,0.0003450129,0.000003799843,0.001048149,0.0000154742,0.00003681871],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1242554,"threshold_uncertainty_score":0.6189744,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0111989750491433,"score_gpt":0.2488756376030628,"score_spread":0.2376766625539195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}