{"id":"W2070170762","doi":"10.1021/bi500239m","title":"Major Change in Regiospecificity for the Exo-1,3-β-glucanase from <i>Candida albicans</i> following Its Conversion to a Glycosynthase","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; University of Otago","keywords":"Chemistry; Stereochemistry; Glycoside hydrolase; Disaccharide; Docking (animal); Hydrolase; Active site; Candida albicans; Acceptor; Glucanase; Enzyme; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525395,0.0003435981,0.000222024,0.0001452225,0.0001458508,0.0006645119,0.0003754067,0.0002271876,0.0010633],"category_scores_gemma":[0.0002861136,0.0001718769,0.0002848081,0.0002016446,0.0002152568,0.0002191082,0.000214624,0.0006372878,0.0002621976],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003793772,"about_ca_system_score_gemma":0.0002763918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001559159,"about_ca_topic_score_gemma":0.001153241,"domain_scores_codex":[0.9998156,0.00001961314,0.00001374612,0.00005171228,0.00004568644,0.0000537434],"domain_scores_gemma":[0.9998511,0.00002759554,0.00003312371,0.00001580941,0.00003051261,0.00004186723],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009642574,0.00001024589,0.0002937012,0.00001011507,0.000006562837,0.00004247804,0.00001719654,0.00004539726,0.998786,0.0000606474,0.00002390128,0.0006073338],"study_design_scores_gemma":[0.000004543827,0.00007985195,0.006550757,0.000002751627,0.00001120284,0.0002015496,0.00003869844,0.000490915,0.9919112,0.00002439059,0.0006766149,0.000007543431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977491,0.0003379203,0.0007027767,0.00004521013,0.000009185204,0.000006001201,0.0002686446,0.00003181458,0.0008493104],"genre_scores_gemma":[0.9964525,0.0001657558,0.0006296589,0.00002797295,0.00000343747,0.000008685273,0.00118883,0.00002601261,0.001497181],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001559159,"threshold_uncertainty_score":0.003557026,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720715299440358,"score_gpt":0.2541254294088472,"score_spread":0.2369182764144436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}