{"id":"W2070170762","doi":"10.1021/bi500239m","title":"Major Change in Regiospecificity for the Exo-1,3-β-glucanase from <i>Candida albicans</i> following Its Conversion to a Glycosynthase","year":2014,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Production and Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of British Columbia; University of Otago","keywords":"Chemistry; Stereochemistry; Glycoside hydrolase; Disaccharide; Docking (animal); Hydrolase; Active site; Candida albicans; Acceptor; Glucanase; Enzyme; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001701857,0.0001503714,0.0001230659,0.00002098846,0.0001011086,0.000028803,0.0002086229,0.0001416442,0.00004512428],"category_scores_gemma":[0.0001906703,0.0001330682,0.00009539877,0.0001040142,0.00002230816,0.000005828526,0.00007190998,0.00006761967,0.00000900686],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003155634,"about_ca_system_score_gemma":0.00003365117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202419,"about_ca_topic_score_gemma":0.00007275782,"domain_scores_codex":[0.9990437,0.00002566636,0.000168341,0.0004414129,0.0001098993,0.0002109716],"domain_scores_gemma":[0.9993469,0.00003014617,0.00006774421,0.0004021277,0.00005170701,0.0001013946],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001652837,0.00003938148,0.0006729143,0.00001950041,0.00002236919,7.829282e-7,0.0000486615,0.000003636566,0.9956173,0.00001023846,0.002282677,0.001117245],"study_design_scores_gemma":[0.0006827345,0.00004731975,0.001486499,0.0000287289,0.00002206637,0.000001537168,0.00008279587,0.0001731007,0.9274033,0.000006870282,0.06988862,0.0001764127],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936113,0.0005335884,0.002341064,0.002554103,0.0003690394,0.0003774958,0.00009648281,0.00001627647,0.0001006132],"genre_scores_gemma":[0.9953585,0.00005106998,0.0001779436,0.002132558,0.0009969447,0.0001716921,0.0004494557,0.00002211596,0.0006397061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.068214,"threshold_uncertainty_score":0.5426365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01720715299440358,"score_gpt":0.2541254294088472,"score_spread":0.2369182764144436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}