{"id":"W2070186790","doi":"10.1021/jm301034u","title":"Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"14-3-3 protein interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Cancer Research UK; Wellcome Trust; Genome Canada; Down Syndrome Research Foundation; GlaxoSmithKline; Ontario Ministry of Research and Innovation; Pfizer; Eli Lilly and Company","keywords":"DYRK1A; Kinase; Neuroprotection; Chemistry; Biochemistry; Pharmacology; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003965821,0.0002061181,0.0003424002,0.00003307275,0.00005791176,0.000009787722,0.0002306258,0.0001425239,0.00002627913],"category_scores_gemma":[0.00082189,0.0001361121,0.0001131752,0.00009922878,0.0003227245,0.00002174433,0.000192189,0.0004620125,1.387952e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003253093,"about_ca_system_score_gemma":0.0001755527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002425094,"about_ca_topic_score_gemma":0.00001150834,"domain_scores_codex":[0.9986074,0.0001131371,0.000522449,0.0001666025,0.0003786318,0.0002117854],"domain_scores_gemma":[0.9984883,0.00004084214,0.0007192153,0.0002383664,0.0003864533,0.0001268188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008464049,0.0001231668,0.003698161,0.0001601513,0.0001659123,0.000008950781,0.0001797288,0.000003972102,0.9929932,0.00000115578,0.0001374354,0.001681732],"study_design_scores_gemma":[0.0009165489,0.0003829186,0.01822856,0.0002895938,0.00009008307,0.0003893749,0.0005411101,0.000005142891,0.978191,0.00003719722,0.0008066471,0.0001218171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938331,0.005239207,0.0001531558,0.000266366,0.0001146592,0.0002503508,0.00002570268,0.000003352925,0.0001141594],"genre_scores_gemma":[0.9982733,0.00009150067,0.0004215469,0.00005316624,0.001054089,0.00001259697,0.00001013868,0.00002288341,0.00006082773],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01480222,"threshold_uncertainty_score":0.5550491,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01126439357158379,"score_gpt":0.2212998351704821,"score_spread":0.2100354415988983,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}