{"id":"W2070213303","doi":"10.2202/1553-3840.1283","title":"Optimized St. John's Wort (Hypericum perforatum L.) Germplasm Lines Exert Cytotoxicity in HT-29 Colon Cancer Cells via Downregulation of NF-?B","year":2010,"lang":"en","type":"article","venue":"Journal of Complementary and Integrative Medicine","topic":"Biological Activity of Diterpenoids and Biflavonoids","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Windsor; University of British Columbia, Okanagan Campus; University of British Columbia; University of Guelph","funders":"","keywords":"Hypericin; Hypericum perforatum; Hyperforin; Pharmacology; Hypericum; Downregulation and upregulation; Tumor necrosis factor alpha; Cancer cell; Cytotoxicity; Medicine; Traditional medicine; Cancer; Chemistry; Biochemistry; Immunology; In vitro; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009702164,0.000361379,0.0002373251,0.000262834,0.00008820883,0.0002043896,0.0001303863,0.0002309425,0.0006113986],"category_scores_gemma":[0.00007983165,0.0001000354,0.0001734929,0.0002164801,0.0001204191,0.0001167225,0.0001245132,0.0003484803,0.0001499176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001429946,"about_ca_system_score_gemma":0.0001050407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003395919,"about_ca_topic_score_gemma":0.000815634,"domain_scores_codex":[0.9999194,0.00001599771,0.00001079709,0.00001542158,0.00002396001,0.00001432137],"domain_scores_gemma":[0.999917,0.00001466066,0.00003246883,0.000008252918,0.00001016112,0.00001754342],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000423992,0.00001235727,0.00005625241,0.00001647256,0.000002335318,0.00001524424,0.000003339445,0.00001303493,0.9994557,0.000008823794,0.000007503662,0.0003664557],"study_design_scores_gemma":[0.00001859993,0.0005343998,0.005669711,0.000004585227,0.00002602097,0.0001966738,0.00002552269,0.0002166641,0.9920082,0.00001976271,0.001275609,0.000004287692],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956149,0.001171667,0.00191491,0.00007719354,0.00001622493,0.00003729072,0.000358473,0.00006714973,0.0007421603],"genre_scores_gemma":[0.9916503,0.0008872774,0.004179138,0.00006636958,0.000009079457,0.00003922237,0.001145738,0.00002217629,0.002000673],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006113986,"threshold_uncertainty_score":0.002045333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0126258459138873,"score_gpt":0.286918111764583,"score_spread":0.2742922658506958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}