{"id":"W2070214007","doi":"10.1021/bi992222j","title":"Copper-Induced Conformational Changes in the N-Terminal Domain of the Wilson Disease Copper-Transporting ATPase","year":2000,"lang":"en","type":"article","venue":"Biochemistry","topic":"Trace Elements in Health","field":"Nursing","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institutes of Health; National Synchrotron Radiation Laboratory; U.S. Department of Energy","keywords":"Copper; ATPase; Chemistry; Wilson's disease; Cysteine; Menkes disease; Conformational change; Binding site; Biophysics; Crystallography; Copper metabolism; Biochemistry; Biology; Enzyme; Medicine; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412451,0.0001596127,0.0001211591,0.00007575919,0.0001552918,0.0001414738,0.0001594098,0.0001939885,0.0006975456],"category_scores_gemma":[0.0002949228,0.00009711392,0.0001669661,0.0000920204,0.0002375632,0.0001583334,0.0001095174,0.0003384628,0.000156921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002056894,"about_ca_system_score_gemma":0.000102084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004387216,"about_ca_topic_score_gemma":0.0004912065,"domain_scores_codex":[0.9999397,0.00001710168,0.000004219529,0.000009548038,0.00001387842,0.00001561145],"domain_scores_gemma":[0.9998674,0.00004168472,0.0000347792,0.00001229533,0.000018564,0.00002519184],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000425703,0.0000867098,0.001057158,0.00004205458,0.00002097851,0.0004045355,0.00008641467,0.0004183653,0.9953681,0.0002275241,0.0001028123,0.001759607],"study_design_scores_gemma":[0.00007719539,0.0007203922,0.02100836,0.00002023468,0.00003373919,0.001396789,0.0001297477,0.002777524,0.9715438,0.0002674648,0.001998009,0.00002667084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991243,0.0001798478,0.0003927865,0.00003032488,0.000006998047,0.000002546474,0.00002466606,0.000006667014,0.0002317716],"genre_scores_gemma":[0.9990237,0.0001152094,0.0003053244,0.00004412388,0.000003626471,0.000003707248,0.0001023524,0.000006215795,0.0003959169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006975456,"threshold_uncertainty_score":0.002333522,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01716122977299311,"score_gpt":0.2858309130143708,"score_spread":0.2686696832413777,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}