{"id":"W2070238977","doi":"10.1128/jb.02205-12","title":"Gene PA2449 Is Essential for Glycine Metabolism and Pyocyanin Biosynthesis in Pseudomonas aeruginosa PAO1","year":2013,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Division of Materials Research; U.S. Department of Agriculture; Pontificia Universidad Católica del Perú; State University of New York; Cooperative State Research, Education, and Extension Service; National Institutes of Health; National Science Foundation","keywords":"Pyocyanin; Biology; Pseudomonas aeruginosa; Biochemistry; Serine; Biosynthesis; Sigma factor; Gene; Secondary metabolism; Virulence; Microbiology; Complementation; Bacteria; Quorum sensing; Genetics; Mutant; Gene expression; Enzyme; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001176727,0.0007891208,0.0004335172,0.0004350936,0.0002956545,0.0003838225,0.0003258932,0.0004897549,0.001311581],"category_scores_gemma":[0.0003772887,0.0002957864,0.0004500536,0.0002492097,0.0003155491,0.0001936243,0.0003792571,0.0006904224,0.001101568],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003053932,"about_ca_system_score_gemma":0.0003685913,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00093682,"about_ca_topic_score_gemma":0.0006872984,"domain_scores_codex":[0.9997776,0.00003919175,0.00002428815,0.00004143297,0.00008536206,0.00003215657],"domain_scores_gemma":[0.999671,0.00009373983,0.00009643353,0.00002980732,0.00002650779,0.00008256448],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005313052,0.00002232336,0.0002271296,0.00002210918,0.000003012898,0.0001943287,0.00001307297,0.00003114973,0.9987708,0.0000416184,0.0000255333,0.0005958502],"study_design_scores_gemma":[0.00002494903,0.0002684838,0.03201995,0.00002334277,0.00002933158,0.002474539,0.0001219145,0.002055932,0.9601155,0.0001745427,0.002659413,0.0000320753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953588,0.0005080036,0.002148021,0.0001521728,0.00003751194,0.00002877973,0.0009775528,0.0001370392,0.0006522895],"genre_scores_gemma":[0.9929903,0.0003078853,0.002552418,0.00005778762,0.00001517088,0.00004470847,0.001877684,0.00008294385,0.002071121],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001311581,"threshold_uncertainty_score":0.004387617,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007704179757827578,"score_gpt":0.2278512517882192,"score_spread":0.2201470720303916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}