{"id":"W2070238977","doi":"10.1128/jb.02205-12","title":"Gene PA2449 Is Essential for Glycine Metabolism and Pyocyanin Biosynthesis in Pseudomonas aeruginosa PAO1","year":2013,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Bacterial biofilms and quorum sensing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Division of Materials Research; U.S. Department of Agriculture; Pontificia Universidad Católica del Perú; State University of New York; Cooperative State Research, Education, and Extension Service; National Institutes of Health; National Science Foundation","keywords":"Pyocyanin; Biology; Pseudomonas aeruginosa; Biochemistry; Serine; Biosynthesis; Sigma factor; Gene; Secondary metabolism; Virulence; Microbiology; Complementation; Bacteria; Quorum sensing; Genetics; Mutant; Gene expression; Enzyme; Promoter","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002506567,0.0001752656,0.0004232739,0.0001119059,0.00004416478,0.00003725147,0.0001242705,0.0002545853,0.00009626802],"category_scores_gemma":[0.00010516,0.0001415876,0.0001343032,0.00005262295,0.0001006131,0.00001585927,0.00007410189,0.0001110598,0.000003023961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000958603,"about_ca_system_score_gemma":0.00005714531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005555683,"about_ca_topic_score_gemma":0.00001536522,"domain_scores_codex":[0.9988383,0.00009013862,0.0005026939,0.0002263493,0.00005660578,0.0002859189],"domain_scores_gemma":[0.9992335,0.00003864295,0.0003125811,0.0001539466,0.0001567574,0.0001045935],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002968401,0.00003793848,0.001097618,0.00001101994,0.00007763926,0.000006069056,0.00004492979,9.317164e-7,0.9913619,0.00001878498,0.000573513,0.00647287],"study_design_scores_gemma":[0.00149278,0.0004763128,0.04430632,0.00001767379,0.00005115689,0.0004097171,0.00005122168,0.00002302357,0.9339367,0.00009075706,0.01894479,0.0001995579],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968963,0.0006178065,0.0001554582,0.001607195,0.0005050066,0.0001680449,0.00002141098,0.000002498911,0.00002628284],"genre_scores_gemma":[0.9927438,0.0006911054,0.005029966,0.0005792014,0.0008623115,0.000005479561,0.00001801901,0.00002035727,0.0000497369],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05742516,"threshold_uncertainty_score":0.5773777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007704179757827578,"score_gpt":0.2278512517882192,"score_spread":0.2201470720303916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}