{"id":"W2070288144","doi":"10.1073/pnas.0700717104","title":"A structural gap in Dpo4 supports mutagenic bypass of a major benzo[ <i>a</i> ]pyrene dG adduct in DNA through template misalignment","year":2007,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Argonne National Laboratory; Division of Materials Research; National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of General Medical Sciences; Canadian Institutes of Health Research; Terry Fox Foundation; National Institutes of Health; National Science Foundation","keywords":"Adduct; Pyrene; DNA; DNA adduct; Chemistry; Benzo(a)pyrene; Genetics; Computational biology; Stereochemistry; Combinatorial chemistry; Biochemistry; Business; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008700617,0.0001103539,0.0001636733,0.0000719624,0.0000411524,0.000006322049,0.0005440711,0.0001358849,0.00001431649],"category_scores_gemma":[0.0001480676,0.00008295309,0.00007335524,0.0003860028,0.0004804675,0.00002687411,0.0001574736,0.0001068474,1.801196e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002455785,"about_ca_system_score_gemma":0.00004302775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002222612,"about_ca_topic_score_gemma":0.000002062957,"domain_scores_codex":[0.9984812,0.000004092685,0.0004513511,0.0002730245,0.000577341,0.0002130089],"domain_scores_gemma":[0.9994808,0.00002182488,0.0003594751,0.00001632683,0.00009209248,0.00002944594],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004924369,0.00003525401,0.02033992,0.00005601175,0.00001173524,5.461011e-8,0.0001402147,0.00002791729,0.978499,0.0004696699,0.0002767005,0.0000942787],"study_design_scores_gemma":[0.0003479323,0.00005809233,0.03004474,0.00005701845,0.000006053333,0.00001437034,0.0002537978,0.000031576,0.9643328,0.004596685,0.0001682218,0.00008868798],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959016,0.0002184386,4.311143e-7,0.0005644838,0.00001810312,0.0001168121,0.00001993644,0.000002076954,0.003158078],"genre_scores_gemma":[0.9989966,0.00003642506,0.0006796605,0.0001419659,0.00005236863,0.000003995111,0.000001507462,0.000004847036,0.00008269081],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01416617,"threshold_uncertainty_score":0.3382729,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02522699183893831,"score_gpt":0.3021738557135464,"score_spread":0.2769468638746081,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}