{"id":"W2070330288","doi":"10.1182/blood-2010-01-266320","title":"A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway","year":2011,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Army Research Office; National Center for Complementary and Integrative Health; Mayo Clinic; National Institute of Arthritis and Musculoskeletal and Skin Diseases; Tampereen Yliopisto; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Cancer Institute; Canadian Cancer Society Research Institute; National Institutes of Health; Peking University; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"JAK-STAT signaling pathway; Suppressor of cytokine signaling 1; Janus kinase; stat; SOCS3; Cancer research; Tyrosine kinase 2; Signal transduction; Cytokine; Janus kinase 2; Myeloproliferative Disorders; Tyrosine kinase; Biology; Janus kinase 1; Cell biology; Polycythemia vera; Autophosphorylation; Phosphorylation; Immunology; STAT3; Platelet-derived growth factor receptor; Suppressor; Receptor; Protein kinase A; Growth factor; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009297724,0.00009753052,0.0001705035,0.00003051674,0.00006360371,0.000004405128,0.00005161503,0.00004935132,0.00008886567],"category_scores_gemma":[0.00007902506,0.00005858443,0.0001022843,0.00005611238,0.0000152222,0.00003163995,0.00002104774,0.00005202158,0.000004477943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001949564,"about_ca_system_score_gemma":0.0000662344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003077132,"about_ca_topic_score_gemma":0.00001080858,"domain_scores_codex":[0.9993602,0.0000232031,0.0001727952,0.0001505199,0.0001701189,0.0001231539],"domain_scores_gemma":[0.9994616,0.00006848133,0.0001040859,0.0001861391,0.0001366986,0.00004299135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006601901,0.009895261,0.1102298,0.0004463216,0.001560114,0.00002983475,0.008434009,0.000005310858,0.6888321,0.1751638,0.0002417615,0.004501519],"study_design_scores_gemma":[0.00308529,0.0005025799,0.005393297,0.0001112115,0.0002254179,0.000009008832,0.0001561128,0.0000168146,0.9871997,0.003177908,0.00006563158,0.00005698317],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959747,0.00003135615,0.001219183,0.0002325489,0.00007620724,0.0008828908,0.00002437036,0.00001810276,0.001540706],"genre_scores_gemma":[0.9967915,0.000009476327,0.002487215,0.0002139299,0.00005840224,0.0002132642,0.000008136555,0.0000148947,0.0002031126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2983676,"threshold_uncertainty_score":0.2389004,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04027488913000221,"score_gpt":0.2491862593325279,"score_spread":0.2089113702025257,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}