{"id":"W2070346682","doi":"10.1074/jbc.m109.046821","title":"Crystal Structure and Functional Analysis of Homocitrate Synthase, an Essential Enzyme in Lysine Biosynthesis","year":2009,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Active site; Stereochemistry; Chemistry; Biosynthesis; Enzyme; Binding site; Lysine; Transferase; Biochemistry; Amino acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001848803,0.0004796642,0.000320174,0.0001492159,0.0003064411,0.0003374705,0.0004522928,0.0003614422,0.0008034839],"category_scores_gemma":[0.0002757625,0.0001771592,0.0002109271,0.0003293652,0.0001794162,0.000163708,0.0001392525,0.0005309259,0.0002302102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006076857,"about_ca_system_score_gemma":0.0007424449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005437498,"about_ca_topic_score_gemma":0.006114285,"domain_scores_codex":[0.9999293,0.00001008321,0.000003344018,0.00001114871,0.00003473166,0.00001140794],"domain_scores_gemma":[0.9999034,0.00001847428,0.00001431257,0.000006331231,0.00002719936,0.00003022032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001614129,0.0005118489,0.006361297,0.000582969,0.0001036349,0.00162675,0.0002783311,0.0095791,0.9410647,0.003242698,0.00590745,0.0291272],"study_design_scores_gemma":[0.001141191,0.0008998874,0.07756077,0.00008715622,0.00027258,0.004126751,0.0007319233,0.1076779,0.7388908,0.00273117,0.06577484,0.0001049806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863015,0.003975637,0.003210506,0.0005088443,0.00007538947,0.00004326686,0.002289602,0.0001528252,0.003442399],"genre_scores_gemma":[0.9759893,0.003145895,0.008246048,0.00007849297,0.00001925326,0.00003336377,0.00982613,0.00004335343,0.002618112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005437498,"threshold_uncertainty_score":0.01081169,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01275084332480116,"score_gpt":0.2355422098010526,"score_spread":0.2227913664762514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}