{"id":"W2070360463","doi":"10.1016/j.neulet.2014.07.033","title":"Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: Implications for drug access to cytoplasmic targets","year":2014,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta","funders":"","keywords":"TRPV1; Capsazepine; Chemistry; Capsaicin; Biophysics; Pharmacology; Dorsal root ganglion; Neuropathic pain; Gabapentin; Agonist; Transient receptor potential channel; Spinal cord; Neuroscience; Biochemistry; Receptor; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571012,0.00009687905,0.0002015725,0.0001020253,0.00006892724,0.00001500823,0.0001722525,0.0000282449,0.000002752754],"category_scores_gemma":[0.0001375694,0.00008401893,0.0000501854,0.0003128855,0.00004183851,0.000177942,0.00004881158,0.0000622384,7.055877e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003000677,"about_ca_system_score_gemma":0.00001762767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003939691,"about_ca_topic_score_gemma":0.00000636971,"domain_scores_codex":[0.9990559,0.00005951824,0.0001761332,0.0003029207,0.000163363,0.0002421909],"domain_scores_gemma":[0.99947,0.00009911771,0.0001238408,0.0002117086,0.00003062656,0.00006473525],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007314599,0.000140044,0.03627234,0.00002877479,0.00000144463,3.911245e-7,0.00007851116,0.000598167,0.9583941,0.00003245383,0.002797395,0.00158329],"study_design_scores_gemma":[0.001136479,0.0002697624,0.4719257,0.00009529713,0.00002343448,0.000002824622,0.000006523245,0.006964161,0.5184841,0.0001164246,0.0008709996,0.0001043311],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576718,0.00000487394,0.0342775,0.007066156,0.0002770253,0.000650108,0.00002064797,0.00001285497,0.00001907937],"genre_scores_gemma":[0.9966862,0.00000451197,0.0005386677,0.002593264,0.00003349452,0.00009067783,0.00001116181,0.00001003837,0.00003199163],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.43991,"threshold_uncertainty_score":0.3426192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02335078183965351,"score_gpt":0.3070365366476376,"score_spread":0.2836857548079841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}