{"id":"W2070362953","doi":"10.1016/j.chom.2012.06.009","title":"Linear Ubiquitination of NEMO Negatively Regulates the Interferon Antiviral Response through Disruption of the MAVS-TRAF3 Complex","year":2012,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Vesicular stomatitis virus; Biology; Signal transducing adaptor protein; Ubiquitin; MDA5; Cell biology; Interferon; RIG-I; Signal transduction; Regulator; Proinflammatory cytokine; NFKB1; Interferon regulatory factors; Virology; Receptor; RNA; Innate immune system; Virus; Immunology; Genetics; RNA interference; Transcription factor; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679054,0.000336572,0.0001900274,0.0001568979,0.0004418041,0.0006017189,0.0003563355,0.0003736549,0.00164701],"category_scores_gemma":[0.000153415,0.0001745368,0.0003251276,0.000114593,0.0004531918,0.0003564024,0.0003691977,0.0007001848,0.0007633767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008475318,"about_ca_system_score_gemma":0.0002732122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006569505,"about_ca_topic_score_gemma":0.001367517,"domain_scores_codex":[0.9998416,0.00002674141,0.00001699848,0.00002907909,0.00003372349,0.00005181423],"domain_scores_gemma":[0.9998293,0.00002054828,0.00005481658,0.00002958732,0.00001707359,0.00004862899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002346248,0.00002023319,0.0002903304,0.00001776875,0.000007725887,0.00007782936,0.000009282106,0.0000701008,0.9983889,0.0002972624,0.00005371894,0.0005322922],"study_design_scores_gemma":[0.0000204236,0.00004038898,0.005212352,0.000003917919,0.00001254673,0.0003066801,0.00005079574,0.001650163,0.990542,0.0002184062,0.001935566,0.00000671224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957566,0.0008418908,0.001618587,0.0002210508,0.00004725525,0.000006956543,0.0001745465,0.00006248256,0.00127066],"genre_scores_gemma":[0.9977382,0.0001489255,0.0004391249,0.00003906278,0.000005193926,0.000003825527,0.0001493512,0.0000189146,0.001457278],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00164701,"threshold_uncertainty_score":0.006149292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0216552793526299,"score_gpt":0.2702929081391421,"score_spread":0.2486376287865122,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}