{"id":"W2070371941","doi":"10.3851/imp1769","title":"Mutations in Gp41 are Correlated with Coreceptor Tropism but Do Not Improve Prediction Methods Substantially","year":2010,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"Canadian Institutes of Health Research; GlaxoSmithKline; Pfizer","keywords":"Maraviroc; Tropism; Gp41; Receiver operating characteristic; Mutation; Biology; Virology; Computational biology; Genetics; Statistics; Human immunodeficiency virus (HIV); Virus; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02170705,0.002680867,0.001623935,0.002000018,0.0006720482,0.002927763,0.0008087034,0.001735884,0.001903084],"category_scores_gemma":[0.0443525,0.0005988411,0.002084189,0.001110093,0.0008753525,0.002132355,0.001394896,0.002371626,0.001565783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005634559,"about_ca_system_score_gemma":0.001101712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002277048,"about_ca_topic_score_gemma":0.003357259,"domain_scores_codex":[0.9894474,0.005386698,0.0008235358,0.002283379,0.001550051,0.0005090259],"domain_scores_gemma":[0.9448562,0.04550758,0.003344059,0.00329254,0.002270994,0.0007286656],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.002134651,0.0004620198,0.665491,0.0005430804,0.005299748,0.0004060446,0.000294252,0.1063176,0.004833898,0.0005692606,0.007650123,0.2059984],"study_design_scores_gemma":[0.0002512921,0.002471593,0.2733507,0.000447685,0.002396158,0.001228378,0.0002479267,0.7007582,0.007326722,0.005679877,0.005659033,0.0001824465],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9128312,0.01021024,0.0608996,0.002217076,0.0004826889,0.0002552601,0.00188365,0.002633836,0.008586343],"genre_scores_gemma":[0.9881677,0.0005909625,0.008340527,0.0003521671,0.0001443174,0.00003881739,0.001510764,0.0001465314,0.0007081841],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02170705,"threshold_uncertainty_score":0.1147992,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017756729943312,"score_gpt":0.3033436694869285,"score_spread":0.2855869395436165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}