{"id":"W2070371941","doi":"10.3851/imp1769","title":"Mutations in Gp41 are Correlated with Coreceptor Tropism but Do Not Improve Prediction Methods Substantially","year":2010,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"AIDS Vancouver","funders":"Canadian Institutes of Health Research; GlaxoSmithKline; Pfizer","keywords":"Maraviroc; Tropism; Gp41; Receiver operating characteristic; Mutation; Biology; Virology; Computational biology; Genetics; Statistics; Human immunodeficiency virus (HIV); Virus; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002346518,0.0001743092,0.0002330073,0.0001348308,0.0001543524,0.00002679726,0.0001297637,0.0002341381,0.0004595626],"category_scores_gemma":[0.00003140289,0.0001230017,0.00006060021,0.0001931274,0.0002561865,0.0001333531,0.00001539117,0.0005781298,0.0003583393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002554481,"about_ca_system_score_gemma":0.00008762164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002164025,"about_ca_topic_score_gemma":0.0003343537,"domain_scores_codex":[0.9987978,0.0002876571,0.0002029491,0.0003002005,0.00005002216,0.0003613537],"domain_scores_gemma":[0.9994218,0.0001457653,0.0000937193,0.0002303097,0.00008255714,0.00002585306],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001082362,0.0002849407,0.04136908,0.000002182389,0.0001824778,0.00002218042,0.0004062555,9.024046e-7,0.8794606,0.000170661,0.00009450426,0.07692384],"study_design_scores_gemma":[0.007537676,0.001400957,0.1964189,0.00002182079,0.00002206877,0.00002999556,0.0002922329,0.00002546025,0.7866691,0.0001232856,0.00724218,0.0002162419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965196,0.0003742101,0.000744204,0.000218157,0.0006738818,0.0004996939,0.000285126,0.00007798772,0.0006071527],"genre_scores_gemma":[0.9963534,0.0002903713,0.001074094,0.00004526721,0.00003308359,0.00007685953,0.0002913262,0.00002146937,0.001814162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1550498,"threshold_uncertainty_score":0.5031888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.017756729943312,"score_gpt":0.3033436694869285,"score_spread":0.2855869395436165,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}