{"id":"W2070396188","doi":"10.1073/pnas.1014188108","title":"LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8 <sup>+</sup> T cells","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"CD40; Cytotoxic T cell; Priming (agriculture); Cell biology; Antigen-presenting cell; T cell; Antigen; CD8; Lymphotoxin; Biology; Dendritic cell; Immune system; Lymphotoxin beta receptor; Immunology; Antigen presentation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002431629,0.0001408222,0.0002822054,0.0003557473,0.0001833701,0.000008997215,0.0007828866,0.000219616,0.0001203574],"category_scores_gemma":[0.0003485477,0.0001029071,0.0001236556,0.0005274182,0.001109919,0.0003925473,0.0001076382,0.0002073977,0.000004376419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000265015,"about_ca_system_score_gemma":0.0001363097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002057668,"about_ca_topic_score_gemma":2.337826e-8,"domain_scores_codex":[0.9986767,0.00006468684,0.0005019011,0.0002623255,0.0002370525,0.0002573488],"domain_scores_gemma":[0.9985766,0.0006281956,0.0004731842,0.00001887653,0.0002916988,0.00001147585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002829781,0.00009972211,0.0004439813,0.00004527794,0.00004802254,1.208789e-8,0.003653766,0.00005090457,0.991397,0.0009807653,0.0002492288,0.0002015619],"study_design_scores_gemma":[0.0006619841,0.0003626023,0.003668278,0.000209406,0.00001972201,0.000007500539,0.001812028,0.00007065322,0.9904113,0.002466774,0.0001999068,0.0001097848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980643,0.001041447,0.000002693973,0.0003271445,0.00006135913,0.0002913481,0.00003675326,0.000007227024,0.0001677334],"genre_scores_gemma":[0.9977582,0.0000670283,0.001519333,0.0001536849,0.00001288749,0.00001526288,4.909891e-7,0.000007500103,0.0004655768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003224297,"threshold_uncertainty_score":0.419643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0703358201748182,"score_gpt":0.2977234260325762,"score_spread":0.227387605857758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}