{"id":"W2070396188","doi":"10.1073/pnas.1014188108","title":"LTβR signaling in dendritic cells induces a type I IFN response that is required for optimal clonal expansion of CD8 <sup>+</sup> T cells","year":2011,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Ontario Institute for Cancer Research; University of Toronto","funders":"University of Toronto; Canadian Institutes of Health Research; Multiple Sclerosis Society; Multiple Sclerosis Society of Canada","keywords":"CD40; Cytotoxic T cell; Priming (agriculture); Cell biology; Antigen-presenting cell; T cell; Antigen; CD8; Lymphotoxin; Biology; Dendritic cell; Immune system; Lymphotoxin beta receptor; Immunology; Antigen presentation; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001768286,0.0003061354,0.0002554734,0.0001176377,0.0001557744,0.0003762284,0.0001096213,0.0003366098,0.001247825],"category_scores_gemma":[0.0001218021,0.0001525042,0.0002801987,0.0001122458,0.0001646114,0.0001448867,0.0002216267,0.0007381696,0.001089013],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004806394,"about_ca_system_score_gemma":0.0001723275,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001845891,"about_ca_topic_score_gemma":0.000316685,"domain_scores_codex":[0.9998174,0.00002946966,0.0000187102,0.00003184871,0.00003926161,0.00006330074],"domain_scores_gemma":[0.9999194,0.00001213854,0.00001936769,0.00001450932,0.000008511699,0.00002616537],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007815835,0.00001448404,0.0000970755,0.00001418687,0.000001602739,0.00003408974,0.000004026865,0.00003350134,0.9991699,0.0000363494,0.00002346892,0.0004931753],"study_design_scores_gemma":[0.00002672022,0.0001314819,0.001929467,0.00000552443,0.000006765666,0.0001773536,0.00001897112,0.0005258466,0.995346,0.00007107156,0.00175867,0.000002166321],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992883,0.001540012,0.002733376,0.0002004734,0.00005825657,0.00002340526,0.0004690898,0.0001019358,0.001990417],"genre_scores_gemma":[0.9946457,0.0007000278,0.001663894,0.0001129545,0.00002950678,0.00003057785,0.0008206303,0.0000319798,0.001964686],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001247825,"threshold_uncertainty_score":0.004174411,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0703358201748182,"score_gpt":0.2977234260325762,"score_spread":0.227387605857758,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}