{"id":"W2070401030","doi":"10.1021/ol071147z","title":"Synthesis of Dihydrooxepin Models Related to the Antitumor Antibiotic MPC1001","year":2007,"lang":"en","type":"article","venue":"Organic Letters","topic":"Advanced Synthetic Organic Chemistry","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Regioselectivity; Amide; Ring (chemistry); Reagent; Pyrrole; Peptide bond; Alcohol; Stereochemistry; Combinatorial chemistry; Proline; Double bond; Antibiotics; Amino acid; Organic chemistry; Biochemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006701411,0.0002548239,0.0001899473,0.000138179,0.00009839104,0.0001850007,0.0002333516,0.0001625701,0.001464107],"category_scores_gemma":[0.0001060649,0.0001160074,0.000126035,0.0001493433,0.0001215101,0.0002012625,0.000124007,0.0003792105,0.0003964728],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000345584,"about_ca_system_score_gemma":0.0002158909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003862075,"about_ca_topic_score_gemma":0.0006113039,"domain_scores_codex":[0.9999501,0.00000931794,0.000003973959,0.0000110229,0.00001292441,0.00001283244],"domain_scores_gemma":[0.9999467,0.000006461791,0.00001633556,0.000006497459,0.000004927596,0.00001908497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001975285,0.00007011557,0.0001403306,0.00007208261,0.000007240708,0.0002642041,0.00002864679,0.001694387,0.9914585,0.001159721,0.00009934686,0.004808045],"study_design_scores_gemma":[0.00006654995,0.001350145,0.0008169005,0.000007522704,0.00002113585,0.0003729906,0.00002085668,0.002226432,0.98593,0.0002623934,0.008916903,0.000008138157],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865158,0.0008934411,0.005488305,0.00007501651,0.00004644849,0.0001313805,0.0006764221,0.0000816094,0.006091618],"genre_scores_gemma":[0.9920136,0.0006616902,0.003819384,0.00002049902,0.000007020538,0.00003300915,0.0004977695,0.00001171289,0.002935393],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464107,"threshold_uncertainty_score":0.004897892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006591697221773912,"score_gpt":0.2156292912630468,"score_spread":0.2090375940412728,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}