{"id":"W2070429530","doi":"10.1016/j.addr.2013.07.005","title":"Chitosans for delivery of nucleic acids","year":2013,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Chitosan; Biocompatibility; Immunogenicity; Gene delivery; Transfection; Nucleic acid; Chemistry; In vivo; Nanotechnology; Rational design; Materials science; Biotechnology; Biochemistry; Biology; Gene; Immune system; Immunology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004527798,0.001327601,0.000952576,0.002098421,0.0002925266,0.0007184113,0.0009512882,0.001060155,0.002663418],"category_scores_gemma":[0.0003883596,0.0003920423,0.0004105743,0.002355382,0.0005741346,0.0009043632,0.0007499726,0.001652363,0.002046067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001093439,"about_ca_system_score_gemma":0.0009682983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002385713,"about_ca_topic_score_gemma":0.003702947,"domain_scores_codex":[0.9997566,0.00002020742,0.00001523799,0.00003152931,0.0001460201,0.00003037342],"domain_scores_gemma":[0.999862,0.00004767406,0.00002659414,0.000006702708,0.00004203487,0.00001493641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009661252,0.0001199998,0.00008013761,0.01369428,0.0001026397,0.0003357636,0.00006752911,0.0009043256,0.07210118,0.008592724,0.02572553,0.8781794],"study_design_scores_gemma":[0.00003978685,0.0001438737,0.0003983281,0.001092525,0.00009065965,0.0009559249,0.00003390506,0.0003962147,0.03375151,0.00156712,0.9614725,0.00005760909],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0008111731,0.9924027,0.002046001,0.0002393642,0.0005724779,0.00002875962,0.0000393656,0.00004781776,0.003812463],"genre_scores_gemma":[0.003766394,0.9891413,0.001605421,0.0002358379,0.0002113962,0.00002975463,0.00007889897,0.000007981998,0.004922961],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002663418,"threshold_uncertainty_score":0.00891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736252076777356,"score_gpt":0.3209708882702887,"score_spread":0.2836083675025152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}