{"id":"W2070429530","doi":"10.1016/j.addr.2013.07.005","title":"Chitosans for delivery of nucleic acids","year":2013,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":false,"ca_institutions":"Polytechnique Montréal","funders":"","keywords":"Chitosan; Biocompatibility; Immunogenicity; Gene delivery; Transfection; Nucleic acid; Chemistry; In vivo; Nanotechnology; Rational design; Materials science; Biotechnology; Biochemistry; Biology; Gene; Immune system; Immunology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000369299,0.0008817276,0.00280858,0.0001625144,0.00009964294,0.00003022801,0.0009930923,0.0004732666,0.00009308053],"category_scores_gemma":[0.000124103,0.0007093477,0.002077419,0.000236729,0.0001364596,0.00002466998,0.0003012002,0.0002703508,0.0003009152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004323327,"about_ca_system_score_gemma":0.0002810718,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001431724,"about_ca_topic_score_gemma":0.00001852191,"domain_scores_codex":[0.996237,0.0002532106,0.001669707,0.001035609,0.0001835227,0.0006209519],"domain_scores_gemma":[0.9969579,0.00008560063,0.001174717,0.001311525,0.0002895232,0.0001807071],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002693854,0.00006677027,0.000002502709,0.01052165,0.0002168544,0.000001232479,0.00001357662,0.000003056506,0.003056231,0.000009319723,0.01145279,0.974629],"study_design_scores_gemma":[0.0003127975,0.0002829404,5.742158e-7,0.007208869,0.0006629551,0.00001722798,0.00001924266,0.000003854434,0.001862058,0.00002153689,0.9888884,0.0007194956],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001212401,0.993512,0.000415346,0.000007054871,0.000592172,0.003397572,0.0003163971,0.00002086396,0.0005262272],"genre_scores_gemma":[0.00003913023,0.9900536,0.004648975,0.0001731231,0.0004585913,0.001327889,0.001252241,0.0001349012,0.001911531],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9774356,"threshold_uncertainty_score":0.9995357,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03736252076777356,"score_gpt":0.3209708882702887,"score_spread":0.2836083675025152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}