{"id":"W2070447685","doi":"10.1038/ncomms7751","title":"The clathrin adaptor AP-1 complex and Arf1 regulate planar cell polarity in vivo","year":2015,"lang":"en","type":"article","venue":"Nature Communications","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; National Eye Institute; Direction Générale de l’offre de Soins; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Canada Research Chairs","keywords":"Dishevelled; Cell biology; Frizzled; Cell polarity; Signal transducing adaptor protein; Small GTPase; Rab; In vivo; Cell; Clathrin; Transport protein; Biology; GTPase; Chemistry; Signal transduction; Wnt signaling pathway; Endocytosis; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001610667,0.0003811222,0.0001238461,0.000291294,0.0002866356,0.0005529444,0.0003067775,0.0004028195,0.0007561078],"category_scores_gemma":[0.0001656155,0.0003193689,0.0001519995,0.00009478709,0.0002947648,0.0003684611,0.0003541263,0.0005153467,0.0006516827],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007378795,"about_ca_system_score_gemma":0.0002823935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008170701,"about_ca_topic_score_gemma":0.001048475,"domain_scores_codex":[0.9998561,0.00001725777,0.000008001033,0.00003031553,0.0000512143,0.0000370168],"domain_scores_gemma":[0.9998338,0.00001881723,0.00005613663,0.00001889675,0.0000212179,0.00005105009],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006612507,0.000005719207,0.000226375,0.00001174964,0.000002348289,0.00003397357,0.00001001449,0.00006226596,0.9976498,0.0005980189,0.00005723488,0.001276272],"study_design_scores_gemma":[0.00003021974,0.00006710396,0.01248734,0.000006436388,0.00001760088,0.0004338968,0.00004093202,0.003537589,0.9757436,0.000756762,0.006867393,0.00001115867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9821579,0.003606815,0.009958616,0.0004188798,0.00006049467,0.00001578598,0.000190677,0.000271781,0.003318934],"genre_scores_gemma":[0.9920983,0.001386545,0.002202807,0.00007095698,0.00002038446,0.00001651398,0.0002170192,0.00004195451,0.003945477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008170701,"threshold_uncertainty_score":0.005353689,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02314978458384278,"score_gpt":0.2789118217694547,"score_spread":0.2557620371856119,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}