{"id":"W2070472280","doi":"10.1016/j.ultras.2008.04.004","title":"Progress and problems in the application of focused ultrasound for blood–brain barrier disruption","year":2008,"lang":"en","type":"review","venue":"Ultrasonics","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":249,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering","keywords":"Blood–brain barrier; Drug delivery; Neuroscience; Central nervous system; Medicine; Focused ultrasound; Drug delivery to the brain; Ultrasound; Biology; Nanotechnology; Materials science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002421458,0.0003411312,0.0007220985,0.0001186452,0.00009032773,0.00004141809,0.0003401116,0.0003122239,0.000002501366],"category_scores_gemma":[0.00008155889,0.0002498973,0.0002087421,0.0004049134,0.0001351404,0.00007331305,0.000008457433,0.0003004379,0.000003648913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003987141,"about_ca_system_score_gemma":0.00005951566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006983321,"about_ca_topic_score_gemma":0.00004361019,"domain_scores_codex":[0.9986188,0.00005517314,0.0005751779,0.0003091236,0.0001655016,0.0002762347],"domain_scores_gemma":[0.9980156,0.001270697,0.0001670287,0.0004572805,0.00004011555,0.00004930207],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000001697083,0.0001745255,0.0001411246,0.0123277,0.0001762553,4.867333e-7,0.001343722,0.0001346972,0.0001562579,0.003251497,0.0003547294,0.9819373],"study_design_scores_gemma":[0.0002836471,0.00003789741,0.00004043378,0.0008253356,0.0002909869,0.0001209628,0.00003766147,0.0002151845,0.000009754085,0.000358749,0.9974697,0.0003097272],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003785194,0.9924094,0.003305269,0.00002270759,0.00003823748,0.003296963,0.0002837669,0.00009301191,0.0001721197],"genre_scores_gemma":[0.002467715,0.9922389,0.001232012,0.00001320807,0.00009334266,0.003445337,0.0004040981,0.00008573225,0.00001965235],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.997115,"threshold_uncertainty_score":0.9999954,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02120105928999672,"score_gpt":0.2763988745602291,"score_spread":0.2551978152702324,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}