{"id":"W2070522618","doi":"10.1158/1078-0432.ccr-12-1397","title":"Serum Lactate Dehydrogenase Is Prognostic for Survival in Patients with Bone Metastases from Breast Cancer: A Retrospective Analysis in Bisphosphonate-Treated Patients","year":2012,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Bone health and treatments","field":"Medicine","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Cancer Research UK; Novartis Pharmaceuticals Corporation","keywords":"Medicine; Lactate dehydrogenase; Internal medicine; Breast cancer; Proportional hazards model; Zoledronic acid; Cancer; Chemotherapy; Oncology; Relative risk; Gastroenterology; Retrospective cohort study; Urology; Surgery; Confidence interval; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001405735,0.000286721,0.001152054,0.0005213893,0.0001165207,0.00002348509,0.0001300849,0.0001970838,0.0004620623],"category_scores_gemma":[0.0004731991,0.0002096533,0.0002104578,0.002618339,0.0002170869,0.0001912645,0.00008973955,0.0007404902,0.00002538742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001096205,"about_ca_system_score_gemma":0.0006151752,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.06081563,"about_ca_topic_score_gemma":0.0390193,"domain_scores_codex":[0.9954652,0.0004952205,0.0008974361,0.000790034,0.001060228,0.001291947],"domain_scores_gemma":[0.9967113,0.0008877761,0.0001984248,0.0004441793,0.0009406742,0.0008176357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.01233055,0.00483131,0.9728973,0.00007152411,0.001109245,0.00002406437,0.000163741,0.000003379604,9.08261e-7,0.000002003702,0.0002180207,0.00834795],"study_design_scores_gemma":[0.01921526,0.001234564,0.9779797,0.0002192267,0.0007207536,1.851166e-7,0.00003630682,0.0001410725,0.00009391597,0.00002719488,0.0001415351,0.0001903465],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884525,0.0008024806,0.000001774633,0.000706539,0.0001454588,0.00282909,0.007011838,0.00002411226,0.00002623103],"genre_scores_gemma":[0.9969215,0.0004108055,0.00008955671,0.0002543261,0.0000605907,0.001246642,0.0008402863,0.00005459174,0.0001216866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02179634,"threshold_uncertainty_score":0.9785161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08758147656428107,"score_gpt":0.4566996469113921,"score_spread":0.369118170347111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}