{"id":"W2070528933","doi":"10.1016/j.antiviral.2009.05.004","title":"Translational insensitivity to potent activation of PKR by HCV IRES RNA","year":2009,"lang":"en","type":"article","venue":"Antiviral Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Internal ribosome entry site; Protein kinase R; RNA; Biology; Translation (biology); EIF-2 kinase; Virology; Eukaryotic translation; Protein biosynthesis; Picornavirus; Interferon; Molecular biology; Ribosome; RNA silencing; Initiation factor; Messenger RNA; Phosphorylation; Cell biology; RNA interference; Biochemistry; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003052166,0.00006234778,0.00007089783,0.00007767215,0.00006758815,0.00001590606,0.00008124186,0.00006404994,0.000007516612],"category_scores_gemma":[0.000155088,0.00005970043,0.0000504545,0.000176981,0.00005743299,0.000007731986,0.00002330444,0.00006490022,0.00001198666],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008144424,"about_ca_system_score_gemma":0.00007997214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003215966,"about_ca_topic_score_gemma":0.000005094068,"domain_scores_codex":[0.9990409,0.000118936,0.000113931,0.0001924569,0.0003561457,0.0001776212],"domain_scores_gemma":[0.9995547,0.00002103156,0.00002148338,0.000155102,0.0001868811,0.00006080827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002490679,0.0001117255,0.0009964337,0.000004141194,0.000006529935,9.96049e-7,0.00002294842,0.00001593254,0.9480635,0.000358407,0.009366163,0.04080414],"study_design_scores_gemma":[0.0002911623,0.000264452,0.123671,0.000009682673,0.000001648976,3.694573e-7,0.00002000903,0.0001294685,0.8711191,0.0003476308,0.004071551,0.000073935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902368,0.00005320128,0.00151718,0.002941365,0.00001279282,0.0001588246,0.00002521576,0.00000497055,0.005049657],"genre_scores_gemma":[0.9984539,0.00001820485,0.0001402365,0.0002300709,0.00006485292,0.000003110063,0.0001164873,0.000005363073,0.0009677863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1226746,"threshold_uncertainty_score":0.2434513,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03611876428698934,"score_gpt":0.3623040886127023,"score_spread":0.326185324325713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}