{"id":"W2070528933","doi":"10.1016/j.antiviral.2009.05.004","title":"Translational insensitivity to potent activation of PKR by HCV IRES RNA","year":2009,"lang":"en","type":"article","venue":"Antiviral Research","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":64,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; National Institutes of Health","keywords":"Internal ribosome entry site; Protein kinase R; RNA; Biology; Translation (biology); EIF-2 kinase; Virology; Eukaryotic translation; Protein biosynthesis; Picornavirus; Interferon; Molecular biology; Ribosome; RNA silencing; Initiation factor; Messenger RNA; Phosphorylation; Cell biology; RNA interference; Biochemistry; Protein kinase A; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006169504,0.0005581963,0.0004909699,0.0004736488,0.0002347449,0.0005078129,0.000241056,0.0003091679,0.00467458],"category_scores_gemma":[0.0006649953,0.0003005708,0.0004597518,0.0002755958,0.0006541861,0.0003655039,0.0004413123,0.001114778,0.0006125465],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004658621,"about_ca_system_score_gemma":0.0003611499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000659378,"about_ca_topic_score_gemma":0.0007679507,"domain_scores_codex":[0.9995871,0.0001097818,0.00006493714,0.00004324191,0.00007769289,0.0001172496],"domain_scores_gemma":[0.9993585,0.0002180086,0.000076953,0.0001454668,0.00003615613,0.0001649405],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001077318,0.0001052023,0.0001637535,0.00004867951,0.00001097343,0.0001288415,0.0000207786,0.0002041486,0.9964898,0.0004035062,0.0001590833,0.001187839],"study_design_scores_gemma":[0.00004371781,0.000903114,0.002185108,0.000006409756,0.00001098609,0.0003764226,0.0000288454,0.0007132442,0.9946926,0.0001084241,0.0009224756,0.000008453135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932473,0.001133659,0.00137427,0.0002629485,0.0001427859,0.0000387325,0.0005771533,0.0001690271,0.003054146],"genre_scores_gemma":[0.9966406,0.0004871983,0.0005861682,0.000116916,0.00005779554,0.00002829073,0.0006941404,0.00004690032,0.001342006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00467458,"threshold_uncertainty_score":0.01563805,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03611876428698934,"score_gpt":0.3623040886127023,"score_spread":0.326185324325713,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}