{"id":"W2070537579","doi":"10.1073/pnas.0809576106","title":"Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 protease","year":2009,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Montreal Clinical Research Institute","funders":"National Institutes of Health","keywords":"Granule (geology); Proteases; Protease; Prohormone convertase; Biochemistry; Chemistry; Signal peptide; Biophysics; Helix (gastropod); Cell biology; Biology; Peptide sequence; Prohormone; Enzyme; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003408315,0.00005811096,0.00007251134,0.00002469493,0.0001279122,0.000008123161,0.0001716281,0.00006180646,0.000006692367],"category_scores_gemma":[0.00007912433,0.00003559311,0.00004556547,0.0001221979,0.0002965429,0.0000197793,0.00002447237,0.0000606169,5.206837e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004101258,"about_ca_system_score_gemma":0.00002179476,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004126453,"about_ca_topic_score_gemma":1.632474e-7,"domain_scores_codex":[0.9992285,0.000004771428,0.000199563,0.0001426271,0.0003601788,0.00006437238],"domain_scores_gemma":[0.9995406,0.00001089698,0.0002940547,0.000007715773,0.0001304046,0.00001633855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004809631,0.000007244677,0.01780628,0.00001052579,0.000006573364,2.327152e-9,0.0001143909,0.000008816042,0.9801836,0.001607064,0.000009757546,0.0001976258],"study_design_scores_gemma":[0.0001327794,0.00004058798,0.5379533,0.00002834118,0.000008074707,0.000002492693,0.00006750639,0.0002733979,0.4492319,0.01217076,0.00005295161,0.00003785061],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987715,0.0001280297,0.00003984857,0.0007878062,0.00001115209,0.0001407842,0.00002663526,0.000001913546,0.00009228281],"genre_scores_gemma":[0.9994733,0.00002110092,0.0002033253,0.0001576296,0.00009697241,0.000002690723,0.00002298941,0.000001738336,0.00002025924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5309517,"threshold_uncertainty_score":0.1451445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247432561895385,"score_gpt":0.2483142614222708,"score_spread":0.225839935803317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}