{"id":"W2070563559","doi":"10.1083/jcb.201202005","title":"ADP ribosylation adapts an ER chaperone response to short-term fluctuations in unfolded protein load","year":2012,"lang":"en","type":"article","venue":"The Journal of Cell Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health; Technische Universität München; Universität Heidelberg; Wellcome Trust; York University; Universität Hamburg","keywords":"Unfolded protein response; Endoplasmic reticulum; Chaperone (clinical); Cell biology; Chemistry; Protein folding; Biophysics; Adenosine triphosphate; Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008504119,0.0001078925,0.0001369086,0.0000674497,0.00004863982,0.000007098848,0.0001997295,0.0001057121,0.00004518684],"category_scores_gemma":[0.000177356,0.00007209733,0.00005306338,0.00007617035,0.0000582124,0.0000114159,0.00005461,0.000108768,0.000008207693],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003106795,"about_ca_system_score_gemma":0.0001173763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001302739,"about_ca_topic_score_gemma":0.0000390943,"domain_scores_codex":[0.9988403,0.000428447,0.0002992163,0.00009770875,0.00009638371,0.0002379597],"domain_scores_gemma":[0.9993346,0.00003629057,0.0001207015,0.000226506,0.0001183012,0.0001635418],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001715494,0.0001282792,0.002809481,0.000003476924,0.00001100553,0.000001781466,0.0002672555,0.000139157,0.9939313,0.00002510159,0.00005346434,0.0009142198],"study_design_scores_gemma":[0.001080417,0.001473672,0.07490505,0.00002515264,0.00004510975,0.00004238293,0.0002670537,0.00006551202,0.9164358,0.0001484678,0.005306877,0.0002045304],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976884,0.0008325732,0.0006036194,0.0002644721,0.0001168349,0.0002001461,0.0000104109,0.000002390592,0.0002811948],"genre_scores_gemma":[0.9990522,0.00007798143,0.0003329752,0.0001300937,0.0002453634,0.000008858009,0.00001780362,0.00001006383,0.000124718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07749551,"threshold_uncertainty_score":0.2940044,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01385658438936143,"score_gpt":0.2775371192205124,"score_spread":0.263680534831151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}