{"id":"W2070582535","doi":"10.1016/s1534-5807(02)00149-1","title":"Attenuation of Leptin Action and Regulation of Obesity by Protein Tyrosine Phosphatase 1B","year":2002,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":546,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada); SickKids Foundation; Hospital for Sick Children; McGill University","funders":"","keywords":"Leptin; Internal medicine; Endocrinology; Leptin receptor; Biology; Protein tyrosine phosphatase; Adipose tissue; Phosphorylation; Obesity; Phosphatase; Cell biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008866628,0.00009800233,0.00009948968,0.00002458155,0.00003713667,0.000004663229,0.00005471738,0.00007187559,0.00007105945],"category_scores_gemma":[0.00002609269,0.0001045336,0.00002036528,0.00007361083,0.0000610421,0.00001089367,0.00006023283,0.00003094984,0.000005837403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001622875,"about_ca_system_score_gemma":0.00001776315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004335347,"about_ca_topic_score_gemma":0.000007312557,"domain_scores_codex":[0.9993632,0.00002373443,0.0002107679,0.0001881503,0.0001177926,0.0000963082],"domain_scores_gemma":[0.9996442,0.000003847438,0.0001614916,0.000106715,0.00004975368,0.00003394419],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004703956,0.0001418033,0.003146334,0.0000711516,0.000008009248,1.978581e-7,0.00002450553,0.000001813229,0.9884853,0.0000561063,0.003451978,0.004565738],"study_design_scores_gemma":[0.0006010321,0.0001124177,0.01022909,0.00002141144,0.000006761597,0.000002565267,0.00002161116,0.00003451622,0.9853097,0.00001530065,0.003538493,0.0001071383],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935899,0.00505782,0.0006383252,0.00002708335,0.00002268231,0.0003105917,0.0001190818,0.000005990921,0.0002285676],"genre_scores_gemma":[0.9933717,0.0001279217,0.004978117,0.00002067847,0.00001365401,0.00001769771,0.0007712418,0.00001009717,0.0006889332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007082757,"threshold_uncertainty_score":0.4262756,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286746777186747,"score_gpt":0.2121460070077151,"score_spread":0.1992785392358477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}