{"id":"W2070599262","doi":"10.1371/journal.pgen.0030027","title":"An Unmethylated 3′ Promoter-Proximal Region Is Required for Efficient Transcription Initiation","year":2007,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Michael Smith Health Research BC; Wellcome Trust; Leukemia and Lymphoma Society","keywords":"Biology; Promoter; TATA box; CpG site; Molecular biology; DNA methylation; Methylation; Epigenetics of physical exercise; Chromatin; Transcription (linguistics); CAAT box; RNA polymerase II; Genetics; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002141287,0.000296761,0.0004647483,0.0001830218,0.0002145217,0.0004350716,0.0003170572,0.0003168266,0.002218146],"category_scores_gemma":[0.0003636799,0.0004429982,0.0004092075,0.0001316869,0.0002534206,0.0002174743,0.0004255706,0.0007644402,0.002452949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564184,"about_ca_system_score_gemma":0.0005192972,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083569,"about_ca_topic_score_gemma":0.001568802,"domain_scores_codex":[0.9996407,0.00003692006,0.00003182356,0.00009650301,0.0001234966,0.00007059234],"domain_scores_gemma":[0.9995395,0.00009991447,0.0001052676,0.00008683254,0.000061452,0.0001071319],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000263576,0.000007397407,0.0002256577,0.00001844813,0.000001686203,0.00002572648,0.00001464174,0.00002686467,0.9988789,0.00004566758,0.00002197491,0.0007067281],"study_design_scores_gemma":[0.00001345917,0.0001304864,0.01994089,0.00001779377,0.00001179309,0.0003959763,0.00003949996,0.001112486,0.9744408,0.0001135526,0.00377579,0.00000740174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764024,0.001638012,0.01744669,0.0002306433,0.00005512481,0.00006094746,0.001189802,0.0005346772,0.002441768],"genre_scores_gemma":[0.9888099,0.0003607539,0.005942294,0.00008283771,0.00001842068,0.00005719289,0.001973518,0.0001168804,0.002638251],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002218146,"threshold_uncertainty_score":0.00742048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03822099819387424,"score_gpt":0.2942754035440702,"score_spread":0.2560544053501959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}