{"id":"W2070602012","doi":"10.1074/jbc.m707720200","title":"Quantitative Analysis of ABCA1-dependent Compartmentalization and Trafficking of Apolipoprotein A-I","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":53,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; Royal Victoria Regional Health Centre; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Heart And Stroke Foundation Of Quebec; Heart and Stroke Foundation of Canada","keywords":"ABCA1; Endocytosis; Endocytic cycle; Cell biology; Lipid-anchored protein; Apolipoprotein B; Hamster; Endosome; Chemistry; Biotinylation; Intracellular; Biology; Biochemistry; Molecular biology; Cholesterol; Cell; Transporter","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001836969,0.00007527138,0.000569023,0.00006922619,0.00001778725,0.000001742789,0.00004839984,0.00007937075,0.00006918438],"category_scores_gemma":[0.0001132174,0.00004825847,0.0001737793,0.0002016482,0.0001596364,0.00002622288,0.00001727488,0.0001130526,1.321259e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001522923,"about_ca_system_score_gemma":0.00002443558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006345285,"about_ca_topic_score_gemma":4.567796e-7,"domain_scores_codex":[0.9991466,0.00002613692,0.0004888583,0.00008227737,0.0001835243,0.00007259323],"domain_scores_gemma":[0.9991711,0.0000530849,0.0004854078,0.00006844824,0.0001440972,0.00007784376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004252997,0.0003022075,0.08276626,0.00007069724,0.0006219218,0.00002000484,0.0003190466,0.00009633957,0.9147916,0.00002259572,0.00001779175,0.0005461599],"study_design_scores_gemma":[0.001714286,0.0004869308,0.4045629,0.0001008036,0.0008880204,0.0002893377,0.0005765078,0.0004475645,0.5906761,0.00002376789,0.0001527725,0.00008100717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983068,0.001115863,0.0002451449,0.00005450051,0.00001980885,0.00004326268,0.00001012391,0.000002949953,0.000201572],"genre_scores_gemma":[0.9987686,0.000415909,0.0006834454,0.00002744641,0.00006201448,4.899552e-7,0.00001135294,0.000002511015,0.00002819705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3241155,"threshold_uncertainty_score":0.1967923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05768506817304404,"score_gpt":0.3075243213842228,"score_spread":0.2498392532111788,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}