{"id":"W2070610191","doi":"10.1634/stemcells.2006-0371","title":"Stage-Specific Conditional Mutagenesis in Mouse Embryonic Stem Cell-Derived Neural Cells and Postmitotic Neurons by Direct Delivery of Biologically Active Cre Recombinase","year":2006,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; European Commission; Volkswagen Foundation; Stem Cell Network","keywords":"Cre recombinase; Biology; Embryonic stem cell; Neural stem cell; Cell biology; Mutagenesis; Cre-Lox recombination; Cellular differentiation; Recombinase; Molecular biology; Genetics; Stem cell; Gene; Transgene; Mutation; Recombination; Genetically modified mouse","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002162413,0.0003552283,0.0004174215,0.0001183349,0.0001033673,0.00004261567,0.000335011,0.0002774037,0.0000554702],"category_scores_gemma":[0.000003043762,0.0003420339,0.0001506,0.0001872704,0.0002653191,0.00001653982,0.0002540335,0.0002241107,0.0000222504],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005671466,"about_ca_system_score_gemma":0.00008894649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001029974,"about_ca_topic_score_gemma":0.00003745758,"domain_scores_codex":[0.9973729,0.0004612977,0.0004800417,0.0008242654,0.0002905365,0.0005709917],"domain_scores_gemma":[0.9989094,0.000145153,0.0002247738,0.0004266282,0.0001385634,0.0001555225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002854941,0.0003469442,0.0007378596,0.0000919973,0.00002835135,0.0000529728,0.0000222865,0.0007853027,0.9951012,0.000004332311,0.002039471,0.0005038244],"study_design_scores_gemma":[0.001256734,0.000572517,0.002639121,0.00001335351,0.00001322724,0.000006345173,0.000216683,0.0002098086,0.9925301,0.000004553731,0.002198959,0.0003386204],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950329,0.002006881,0.0000347107,0.00005022787,0.0001304507,0.0006108182,0.001442243,0.00002181288,0.0006699248],"genre_scores_gemma":[0.9901568,0.001225187,0.00006069147,0.00004843624,0.00004385337,0.00003513391,0.0003771034,0.00004719901,0.008005585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00733566,"threshold_uncertainty_score":0.9999031,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117256974511373,"score_gpt":0.2164174918936689,"score_spread":0.2046917944425315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}