{"id":"W2070610191","doi":"10.1634/stemcells.2006-0371","title":"Stage-Specific Conditional Mutagenesis in Mouse Embryonic Stem Cell-Derived Neural Cells and Postmitotic Neurons by Direct Delivery of Biologically Active Cre Recombinase","year":2006,"lang":"en","type":"article","venue":"Stem Cells","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"University of Toronto; European Commission; Volkswagen Foundation; Stem Cell Network","keywords":"Cre recombinase; Biology; Embryonic stem cell; Neural stem cell; Cell biology; Mutagenesis; Cre-Lox recombination; Cellular differentiation; Recombinase; Molecular biology; Genetics; Stem cell; Gene; Transgene; Mutation; Recombination; Genetically modified mouse","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005188603,0.0004777134,0.0002803229,0.0002774741,0.0001639659,0.0002621958,0.0004850201,0.0003853181,0.0009532892],"category_scores_gemma":[0.000191664,0.0003476501,0.0003729707,0.0001715648,0.000328703,0.0002644866,0.0002972729,0.0006615988,0.0006753918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002781492,"about_ca_system_score_gemma":0.000411046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004445513,"about_ca_topic_score_gemma":0.0009209601,"domain_scores_codex":[0.999651,0.00006778951,0.00005859039,0.00006136273,0.0001222725,0.0000390407],"domain_scores_gemma":[0.9998247,0.00003331079,0.00006223012,0.00003849678,0.00001516844,0.00002613327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001174422,0.000006733781,0.00002699808,0.00002070198,0.000001611155,0.00002058502,0.000008897989,0.00003512339,0.9990156,0.000175656,0.00001066869,0.000665648],"study_design_scores_gemma":[0.000007699166,0.00007600457,0.0004797506,0.000004579205,0.000008114386,0.0001493581,0.000006015923,0.000346136,0.9964191,0.00004443869,0.002456433,0.000002404072],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8603328,0.003683174,0.1298993,0.0001963717,0.0001085811,0.0006567052,0.001105936,0.000471847,0.003545146],"genre_scores_gemma":[0.906583,0.004556297,0.07427412,0.0001199039,0.00002665773,0.0006426548,0.002230968,0.0001857673,0.01138063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009532892,"threshold_uncertainty_score":0.003189087,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0117256974511373,"score_gpt":0.2164174918936689,"score_spread":0.2046917944425315,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}