{"id":"W2070622422","doi":"10.1371/journal.pgen.1001385","title":"Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Defence Science and Technology Group; Ministry of Education - Singapore; Ontario Ministry of Health and Long-Term Care","keywords":"Biology; Genome instability; DNA damage; Cell biology; Effector; Suppressor; Mitosis; Cell cycle checkpoint; Mitotic catastrophe; Programmed cell death; Cell cycle; Cancer research; Apoptosis; Genetics; DNA; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007665782,0.0001088698,0.000146336,0.00004678312,0.00002573029,0.000003501044,0.00008921358,0.0000993166,0.00001034348],"category_scores_gemma":[0.00004073316,0.0001064954,0.00001800512,0.0000528319,0.00005881715,0.000002960096,0.0002073194,0.00002318569,3.696834e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002363202,"about_ca_system_score_gemma":0.0001197612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002415874,"about_ca_topic_score_gemma":0.00004220215,"domain_scores_codex":[0.999297,0.00002909359,0.0002252126,0.0002398911,0.0000862583,0.0001225664],"domain_scores_gemma":[0.9995154,0.000006344222,0.0001043602,0.0002108546,0.00009538732,0.00006768521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001129458,0.0000700183,0.02744053,0.00008495367,0.00003356473,1.451887e-7,0.0008532446,0.000004327667,0.9681609,0.000005470506,0.00001106489,0.003222796],"study_design_scores_gemma":[0.0003270631,0.000244276,0.05594808,0.0000325978,0.00002025852,0.000001227025,0.00006500702,0.00005723152,0.9430307,0.00003999451,0.0001245065,0.0001090366],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987751,0.0007632319,0.00004739103,0.000007204028,0.00004896153,0.0002356053,0.00001239312,0.00000593606,0.0001041331],"genre_scores_gemma":[0.9932137,0.0002440985,0.006415988,0.0000238055,0.00002279432,0.000023348,0.00001195638,0.00001715863,0.00002716828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02850755,"threshold_uncertainty_score":0.4342755,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861788437239871,"score_gpt":0.253518773356575,"score_spread":0.2249008889841763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}