{"id":"W2070622422","doi":"10.1371/journal.pgen.1001385","title":"Inactivation of Chk2 and Mus81 Leads to Impaired Lymphocytes Development, Reduced Genomic Instability, and Suppression of Cancer","year":2011,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Ontario Institute for Cancer Research; University Health Network","funders":"Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Defence Science and Technology Group; Ministry of Education - Singapore; Ontario Ministry of Health and Long-Term Care","keywords":"Biology; Genome instability; DNA damage; Cell biology; Effector; Suppressor; Mitosis; Cell cycle checkpoint; Mitotic catastrophe; Programmed cell death; Cell cycle; Cancer research; Apoptosis; Genetics; DNA; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009388009,0.0005415487,0.0001919423,0.0003867694,0.0001633954,0.000249833,0.000272897,0.0003024231,0.001776378],"category_scores_gemma":[0.00008412357,0.0001843515,0.0001804819,0.0002102352,0.0002720994,0.0001733735,0.0003419885,0.0004885976,0.000322289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002872504,"about_ca_system_score_gemma":0.0001860146,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000391534,"about_ca_topic_score_gemma":0.0008016099,"domain_scores_codex":[0.9998318,0.00001996329,0.00001785921,0.00003895534,0.00004419867,0.00004713322],"domain_scores_gemma":[0.9998456,0.00001743579,0.00005538531,0.00002136412,0.000006664933,0.00005347043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001230135,0.00001549281,0.0002137287,0.00001394126,0.000005291557,0.00005795911,0.000004952848,0.00004650134,0.9987619,0.0001074304,0.00002099933,0.0006288622],"study_design_scores_gemma":[0.00001889617,0.0001761719,0.004339432,0.000003066954,0.00001608838,0.0004689445,0.00001681958,0.000492117,0.992723,0.0000534522,0.001688175,0.000003756199],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966635,0.0006602452,0.001081191,0.00004785045,0.00001348469,0.000008737164,0.0002875581,0.00007415422,0.001163373],"genre_scores_gemma":[0.9951592,0.000242115,0.0006475367,0.0000181044,0.000004230513,0.00001586759,0.0003704018,0.00001894482,0.003523486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001776378,"threshold_uncertainty_score":0.005942523,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02861788437239871,"score_gpt":0.253518773356575,"score_spread":0.2249008889841763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}