{"id":"W2070628135","doi":"10.1016/s0006-3223(01)01140-4","title":"Clinical and neurochemical effect of acute tryptophan depletion in unaffected relatives of patients with bipolar affective disorder","year":2001,"lang":"en","type":"article","venue":"Biological Psychiatry","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University","funders":"","keywords":"Serotonergic; Impulsivity; Psychology; Internal medicine; Placebo; Serotonin; Mood; Bipolar disorder; Proband; Endocrinology; Crossover study; Imipramine; Major depressive disorder; Psychiatry; Medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001295071,0.0001699159,0.0004963331,0.00006620988,0.00002014137,0.000001393868,0.00004398091,0.0002144834,0.00001545373],"category_scores_gemma":[0.00007532431,0.00009384127,0.0001059895,0.0002430201,0.0003071961,0.00002715161,0.00003019762,0.0002188724,0.000001282708],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001022394,"about_ca_system_score_gemma":0.00001760247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002035785,"about_ca_topic_score_gemma":0.0000302751,"domain_scores_codex":[0.9988384,0.0002809555,0.0003090759,0.000306992,0.0001133134,0.000151251],"domain_scores_gemma":[0.9994137,0.0002107889,0.0001133656,0.0001467502,0.00003459314,0.00008079217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004510343,0.001551045,0.9896324,0.00004485583,0.0001767045,0.0000018135,0.00003493923,1.522721e-7,0.0004848482,0.00007179243,0.000003732971,0.003487376],"study_design_scores_gemma":[0.007785844,0.0100439,0.98146,0.00007324014,0.0001778169,0.000006707114,0.00001369631,0.000007856144,0.0001763552,0.0001155502,0.0000501029,0.00008896951],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972519,0.001697896,0.00006253205,0.00009424365,0.00007211389,0.0006433476,0.00002551625,0.00002186143,0.0001305961],"genre_scores_gemma":[0.9991201,0.0002851706,0.000457716,0.00002087898,0.00002160653,0.00001629742,0.00006548227,0.000008768647,0.000003953771],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008492854,"threshold_uncertainty_score":0.3826736,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008577884461957962,"score_gpt":0.2849352695493005,"score_spread":0.2763573850873425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}