{"id":"W2070637069","doi":"10.1038/ja.2009.22","title":"JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634","year":2009,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nutrasource","funders":"Japan Society for the Promotion of Science","keywords":"Streptomyces; Trichostatin A; Beta-lactam; Chemistry; Microbiology; Biology; Computational biology; Bacteria; Biochemistry; Genetics; Antibiotics; Histone deacetylase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005726662,0.0001468308,0.0002119099,0.00008343224,0.0001011528,0.00003540988,0.0004605699,0.0001191446,0.00002819782],"category_scores_gemma":[0.0002486805,0.0001001061,0.0001367104,0.0001825347,0.0001201801,0.000007568665,0.00005735538,0.0003141889,0.0000116876],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002702024,"about_ca_system_score_gemma":0.0001673287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002988353,"about_ca_topic_score_gemma":0.00002142685,"domain_scores_codex":[0.9987097,0.0001043647,0.0004161439,0.0001333397,0.0003781855,0.0002582109],"domain_scores_gemma":[0.9989094,0.0000683496,0.0003092667,0.000336171,0.0002575128,0.0001192664],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000260392,0.0001895055,0.0007663271,0.0000032631,0.00008116639,0.00002083344,0.0001576468,0.00018906,0.9748689,0.00001588861,0.02141514,0.002031908],"study_design_scores_gemma":[0.001032686,0.001201138,0.007053806,0.00004915732,0.00007086076,0.0001265077,0.0002725367,0.0001380154,0.9743912,0.00008500813,0.01540809,0.000171051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943289,0.001056326,0.002643294,0.0008930478,0.0001527226,0.00008163507,0.00004480714,0.000004468297,0.0007947788],"genre_scores_gemma":[0.9958233,0.0005776851,0.002052119,0.0003470372,0.0006750872,6.48561e-9,0.00002041453,0.00001541868,0.0004889295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006287478,"threshold_uncertainty_score":0.4082207,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182082442933731,"score_gpt":0.280563634443887,"score_spread":0.2687428100145497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}