{"id":"W2070637069","doi":"10.1038/ja.2009.22","title":"JBIR-17, a novel trichostatin analog from Streptomyces sp. 26634","year":2009,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":false,"ca_institutions":"Nutrasource","funders":"Japan Society for the Promotion of Science","keywords":"Streptomyces; Trichostatin A; Beta-lactam; Chemistry; Microbiology; Biology; Computational biology; Bacteria; Biochemistry; Genetics; Antibiotics; Histone deacetylase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007360313,0.000402059,0.0003542852,0.0002788555,0.0001232729,0.0002455612,0.0002870092,0.0001736794,0.001591324],"category_scores_gemma":[0.00007432141,0.0001033454,0.0002384583,0.0002536031,0.0001679145,0.0001489106,0.0001668269,0.00040457,0.0005747892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002036094,"about_ca_system_score_gemma":0.0003191044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007843561,"about_ca_topic_score_gemma":0.001057788,"domain_scores_codex":[0.9999495,0.000007147443,0.000005757703,0.000007012127,0.00001406902,0.00001654805],"domain_scores_gemma":[0.999963,0.000003457465,0.000006916055,0.000003538377,0.000004984517,0.00001808942],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006682185,0.00009146416,0.0003505214,0.0002296838,0.00002440032,0.0005327063,0.00001953059,0.0004158775,0.9815155,0.0001779998,0.0003134601,0.01566052],"study_design_scores_gemma":[0.0002118593,0.002823919,0.003147402,0.00002321578,0.000081827,0.001270432,0.00004519891,0.0005937577,0.9729848,0.00008642044,0.01871039,0.00002076081],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.972887,0.009776815,0.004365046,0.0002361477,0.000249202,0.0002270302,0.002065408,0.0002759278,0.009917395],"genre_scores_gemma":[0.9795445,0.006399223,0.00470727,0.0001370007,0.00004524935,0.00004196214,0.003781879,0.00003890851,0.005304042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001591324,"threshold_uncertainty_score":0.005323529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182082442933731,"score_gpt":0.280563634443887,"score_spread":0.2687428100145497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}