{"id":"W2070645153","doi":"10.4161/mabs.1.5.9631","title":"Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors","year":2009,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Monoclonal antibody; Receptor; Fc receptor; Dissociation constant; In vitro; Biochemistry; Affinities; Surface plasmon resonance; Antigen; Cell surface receptor; Antibody; Ligand binding assay; Binding site; Plasma protein binding; Biophysics; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001755819,0.0001410893,0.0003078021,0.0003055709,0.00004495418,0.0000114606,0.00007485269,0.00007105106,0.0004183243],"category_scores_gemma":[0.00004748542,0.0001172636,0.0000644769,0.0002614773,0.00009264793,0.00005626134,0.00005174314,0.0001934011,0.0000522388],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000438435,"about_ca_system_score_gemma":0.00003711864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004312943,"about_ca_topic_score_gemma":0.0000124797,"domain_scores_codex":[0.9988477,0.00003395825,0.0002515834,0.0002290758,0.0003143027,0.0003233464],"domain_scores_gemma":[0.9994985,0.0001003314,0.00003789199,0.0001200403,0.00004913447,0.0001940725],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.006528441,0.0004454796,0.06757326,0.0002405966,0.0001292459,0.0002024446,0.002699353,0.00002178769,0.7891363,0.001219613,0.007516381,0.1242871],"study_design_scores_gemma":[0.004800809,0.002184856,0.5215586,0.0006555812,0.00007342412,0.00006351859,0.001528267,0.0004775881,0.3875459,0.0005101216,0.0798436,0.0007577266],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877779,0.0004177518,0.000002654965,0.005153304,0.000117562,0.0002273353,0.00001795061,0.00001875236,0.006266741],"genre_scores_gemma":[0.9898995,0.0001195965,0.001813168,0.0006066987,0.00008184512,0.000007322459,0.00002684601,0.00001215889,0.007432921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4539854,"threshold_uncertainty_score":0.478187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937826063259757,"score_gpt":0.311094447734828,"score_spread":0.2817161871022305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}