{"id":"W2070645153","doi":"10.4161/mabs.1.5.9631","title":"Dimers and multimers of monoclonal IgG1 exhibit higher in vitro binding affinities to Fcγ receptors","year":2009,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women's Health Research Institute","funders":"","keywords":"Chemistry; Monoclonal antibody; Receptor; Fc receptor; Dissociation constant; In vitro; Biochemistry; Affinities; Surface plasmon resonance; Antigen; Cell surface receptor; Antibody; Ligand binding assay; Binding site; Plasma protein binding; Biophysics; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004349411,0.000581865,0.0003473517,0.0003662174,0.0001480025,0.0004217753,0.0003169018,0.0004543911,0.002105656],"category_scores_gemma":[0.0004677006,0.0002801709,0.0002980446,0.0003059037,0.0001095775,0.0001595289,0.0002178055,0.0005961106,0.0007645098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005099212,"about_ca_system_score_gemma":0.0001065994,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008459521,"about_ca_topic_score_gemma":0.0008007212,"domain_scores_codex":[0.9995837,0.0000933501,0.00003298735,0.0001028139,0.00009148529,0.00009568485],"domain_scores_gemma":[0.9997492,0.00005863718,0.00006766666,0.00002930102,0.00004629876,0.00004893301],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008334603,0.00003423272,0.0004235407,0.00004986045,0.0000173105,0.00002141759,0.00002158818,0.00007153386,0.997652,0.00003423426,0.0001053746,0.001485464],"study_design_scores_gemma":[0.00003901125,0.00053802,0.01612587,0.00001510896,0.00007540504,0.0003035796,0.00003388719,0.001028551,0.9737967,0.00006623846,0.007963608,0.00001398249],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9885866,0.006490277,0.00304796,0.0001473532,0.00004696306,0.00003188955,0.0002600304,0.0001110657,0.001277825],"genre_scores_gemma":[0.9860042,0.002032388,0.00441381,0.000278658,0.00004831233,0.00005928192,0.001394381,0.0000508925,0.005718125],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105656,"threshold_uncertainty_score":0.007044137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02937826063259757,"score_gpt":0.311094447734828,"score_spread":0.2817161871022305,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}