{"id":"W2070663007","doi":"10.1038/sj.onc.1209397","title":"Functional characterization of novel presenilin-2 variants identified in human breast cancers","year":2006,"lang":"en","type":"article","venue":"Oncogene","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institutes of Health Research; Toronto Public Health; Occupational Cancer Research Centre; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Public Health Ontario; University of Toronto","funders":"National Cancer Institute","keywords":"Biology; Presenilin; Allele; Breast cancer; Caenorhabditis elegans; Germline; Carcinogenesis; Genetics; Gene; Cancer research; Phenotype; Cancer; Disease; Alzheimer's disease; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001490053,0.0002980525,0.000260272,0.0007431495,0.0002648121,0.0003890106,0.0002286712,0.0002838222,0.00102643],"category_scores_gemma":[0.0005046906,0.000140415,0.0002868574,0.000429856,0.0001894602,0.0001061104,0.0001658899,0.0002459722,0.0002864253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691723,"about_ca_system_score_gemma":0.0001650695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002286403,"about_ca_topic_score_gemma":0.00225652,"domain_scores_codex":[0.9998794,0.00001413078,0.00002199193,0.0000262946,0.00003527641,0.00002282986],"domain_scores_gemma":[0.9998177,0.00004863204,0.00004030776,0.00002111218,0.00003953153,0.00003272888],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005492785,0.00003053326,0.006331589,0.00004854425,0.00007250228,0.002123754,0.0001149139,0.0001512326,0.9874926,0.0001628758,0.0001466624,0.002775519],"study_design_scores_gemma":[0.0001546,0.0006079067,0.2348263,0.00002565381,0.0005074206,0.04022335,0.000436196,0.002703617,0.7097905,0.0003719862,0.01031262,0.0000398934],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978629,0.0006118465,0.0004981143,0.00003997509,0.00001646115,0.00001192792,0.0004866999,0.00001496469,0.0004571292],"genre_scores_gemma":[0.997215,0.0002898433,0.000766723,0.00004476226,0.000008020916,0.00001103788,0.001022109,0.00001365639,0.0006288281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002286403,"threshold_uncertainty_score":0.004546106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03314513162957747,"score_gpt":0.3079405649441215,"score_spread":0.274795433314544,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}