{"id":"W2070664784","doi":"10.1016/j.bbapap.2014.08.014","title":"Reactivity of ligand-swapped mutants of the SCO protein from Bacillus subtilis. Isomers of the CCH metal binding motif","year":2014,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Bacillus subtilis; Mutant; Chemistry; Ligand (biochemistry); Reactivity (psychology); Metal; Motif (music); Stereochemistry; Biochemistry; Biology; Receptor; Genetics; Organic chemistry; Bacteria; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002020524,0.0003720717,0.0002826101,0.0001870511,0.0002002128,0.0002641643,0.00033446,0.000446495,0.001427507],"category_scores_gemma":[0.0003741252,0.0001448784,0.0002093942,0.0002660547,0.0003440744,0.000129242,0.0001816887,0.0005423439,0.0002414021],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005291048,"about_ca_system_score_gemma":0.000210005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004662592,"about_ca_topic_score_gemma":0.002499993,"domain_scores_codex":[0.9997686,0.00004794078,0.00001530942,0.00003989149,0.00006410739,0.00006427555],"domain_scores_gemma":[0.9997229,0.00007643416,0.00005843417,0.0000204947,0.00004003704,0.00008171445],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007054721,0.00006265611,0.000950103,0.00003687091,0.00002265697,0.0001957763,0.00005857969,0.00038258,0.9967043,0.0001296395,0.0001271931,0.000624183],"study_design_scores_gemma":[0.00003842168,0.0002260354,0.007060142,0.000008924021,0.00002376646,0.0004717592,0.0001055486,0.002905537,0.9881315,0.00005122565,0.0009572498,0.00001984891],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988177,0.0001753672,0.0003200706,0.00005427619,0.00001454017,0.000003386004,0.0001897687,0.00001902597,0.000405791],"genre_scores_gemma":[0.9985014,0.00009035463,0.0002785846,0.00003083893,0.000003470217,0.000005296447,0.0004512369,0.00001655385,0.0006222608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004662592,"threshold_uncertainty_score":0.009270906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00917583709616103,"score_gpt":0.204287563007993,"score_spread":0.195111725911832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}