{"id":"W2070720108","doi":"10.1371/journal.pone.0021970","title":"Functional Modifications of Acid-Sensing Ion Channels by Ligand-Gated Chloride Channels","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre; Western University","funders":"Canadian Institutes of Health Research; Canadian Stroke Network; Heart and Stroke Foundation of Canada","keywords":"GABAA receptor; Acid-sensing ion channel; Chloride channel; Ion channel; Glycine receptor; Chemistry; Receptor; Ligand-gated ion channel; Sodium channel; Cell biology; Biophysics; Hippocampal formation; gamma-Aminobutyric acid; GABAA-rho receptor; Patch clamp; Neuroscience; Biology; Biochemistry; Sodium; Glycine; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008254407,0.000119836,0.0001431016,0.00005366172,0.00007245207,0.000006660393,0.00007736946,0.0001453652,0.00004453722],"category_scores_gemma":[0.00001684004,0.0001245391,0.00006373237,0.0001071878,0.00005699177,0.000007539603,0.00001602262,0.00005609285,0.00001443546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000818885,"about_ca_system_score_gemma":0.00002577617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001999556,"about_ca_topic_score_gemma":0.00000330916,"domain_scores_codex":[0.9991814,0.00001450472,0.0002276499,0.0002352137,0.0001769554,0.0001642118],"domain_scores_gemma":[0.9994136,0.000002694531,0.0001084331,0.0002084385,0.0002047752,0.00006206973],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001451067,0.0004057442,0.0001365188,0.00002824158,0.0001202115,3.86455e-7,0.0001568719,0.0000317077,0.9985073,0.00006580426,0.0002884271,0.0001136789],"study_design_scores_gemma":[0.000331122,0.0001286537,0.0009176044,0.00003885163,0.00005869288,0.000001401091,0.00004434744,0.0004543416,0.9975674,0.0001648664,0.0001566591,0.0001361085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916155,0.0001851914,0.007200671,0.000101613,0.0001836693,0.0001681031,0.00003098407,0.00002342325,0.0004908997],"genre_scores_gemma":[0.9970873,0.0000893891,0.000360375,0.00004268795,0.0003414746,0.000009624638,0.000815899,0.00002095827,0.001232279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006840296,"threshold_uncertainty_score":0.5078559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05523624954541935,"score_gpt":0.2102397429280267,"score_spread":0.1550034933826074,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}