{"id":"W2070736537","doi":"10.1038/ncomms1345","title":"MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Astellas Foundation for Research on Metabolic Disorders; Foundation for Promotion of Cancer Research; Ministry of Education, Culture, Sports, Science and Technology; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Senri Life Science Foundation; Astellas Pharma; Ministry of Health, Labour and Welfare; Takeda Science Foundation","keywords":"Regulator; Hepatocellular carcinoma; Key (lock); Cancer research; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001368668,0.00009077526,0.0001092764,0.00003535725,0.0001023656,0.000004810448,0.0006488949,0.0002094495,0.00001269313],"category_scores_gemma":[0.00006679559,0.00006822585,0.00006037718,0.00008898702,0.0003642379,0.000005890052,0.0003869467,0.0001427817,5.254252e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005114809,"about_ca_system_score_gemma":0.00005672884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005042801,"about_ca_topic_score_gemma":0.00001760885,"domain_scores_codex":[0.9993424,0.0001279199,0.0002121283,0.00014438,0.00009389561,0.00007926171],"domain_scores_gemma":[0.9980432,0.00002271638,0.0002719818,0.001423446,0.0002059942,0.00003269548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003560906,0.00005277372,0.07007856,0.00002819929,0.0000237749,1.499473e-7,0.0003916149,4.438034e-7,0.9285071,0.0004129898,0.0002248276,0.0002439627],"study_design_scores_gemma":[0.000159905,0.00002938639,0.1461396,0.00005684,0.00002435029,0.000003503007,0.00007515807,0.00004002823,0.8502596,0.0001940823,0.002951045,0.00006648276],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9673076,0.03198949,0.00004326761,0.0001760355,0.00002079666,0.0002417406,0.0000404735,0.000003847231,0.00017679],"genre_scores_gemma":[0.9964017,0.0004418551,0.002979393,0.00005568001,0.00001433322,0.00002852665,0.00004483543,0.00001004622,0.00002362152],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07824752,"threshold_uncertainty_score":0.278217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189917485474865,"score_gpt":0.2584490249771247,"score_spread":0.2394572764296382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}