{"id":"W2070736537","doi":"10.1038/ncomms1345","title":"MicroRNA122 is a key regulator of α-fetoprotein expression and influences the aggressiveness of hepatocellular carcinoma","year":2011,"lang":"en","type":"article","venue":"Nature Communications","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Astellas Foundation for Research on Metabolic Disorders; Foundation for Promotion of Cancer Research; Ministry of Education, Culture, Sports, Science and Technology; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Senri Life Science Foundation; Astellas Pharma; Ministry of Health, Labour and Welfare; Takeda Science Foundation","keywords":"Regulator; Hepatocellular carcinoma; Key (lock); Cancer research; Biology; Computational biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001518238,0.0002970534,0.000272626,0.0002732565,0.0002252535,0.0004890136,0.00009189578,0.0002579243,0.001001045],"category_scores_gemma":[0.0003224319,0.0001810236,0.0001903322,0.0001640603,0.0001797652,0.0001674404,0.000159243,0.0002406757,0.0003840824],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000250885,"about_ca_system_score_gemma":0.0001591512,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003475313,"about_ca_topic_score_gemma":0.0003785549,"domain_scores_codex":[0.99983,0.00003857633,0.00001433438,0.00003873836,0.00004850036,0.00002988442],"domain_scores_gemma":[0.9998759,0.00001860666,0.00004517534,0.000008114227,0.0000248813,0.0000272228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001262312,0.000009688403,0.002221404,0.00002608634,0.000007646381,0.0002500825,0.00002035314,0.00007555557,0.993044,0.000140058,0.000127091,0.003951766],"study_design_scores_gemma":[0.00003482907,0.0004403976,0.07325705,0.00001777453,0.00006138155,0.00237216,0.0001080803,0.003070479,0.9077363,0.0004033134,0.01247254,0.00002572866],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9819127,0.007592551,0.005132982,0.0002559513,0.00008533755,0.00003159682,0.0002638331,0.0002547427,0.004470214],"genre_scores_gemma":[0.9956157,0.001363315,0.001209165,0.00004245104,0.00001768024,0.00001577137,0.0001492377,0.0000231574,0.001563519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001045,"threshold_uncertainty_score":0.003348768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0189917485474865,"score_gpt":0.2584490249771247,"score_spread":0.2394572764296382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}