{"id":"W2070745850","doi":"10.1111/j.1365-2958.2008.06303.x","title":"The PhoQ histidine kinases of <i>Salmonella</i> and <i>Pseudomonas</i> spp. are structurally and functionally different: evidence that pH and antimicrobial peptide sensing contribute to mammalian pathogenesis","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Periplasmic space; Biology; Biochemistry; Divalent; Peptide; Antimicrobial peptides; Mutant; Virulence; Peptide sequence; Histidine; Histidine kinase; Microbiology; Escherichia coli; Chemistry; Amino acid; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009114663,0.0003562036,0.000163797,0.0001847451,0.0001186308,0.0003064946,0.0002096847,0.0003065504,0.0006101229],"category_scores_gemma":[0.0001767428,0.0001578672,0.0002584402,0.0001340257,0.000276989,0.0003232796,0.0003158263,0.000331063,0.0003306737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586061,"about_ca_system_score_gemma":0.0001593243,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006922507,"about_ca_topic_score_gemma":0.0005619533,"domain_scores_codex":[0.9998889,0.00001212313,0.000009797803,0.00002470083,0.00003171979,0.00003279035],"domain_scores_gemma":[0.9998097,0.00001795456,0.00007772243,0.00001378822,0.0000255527,0.00005542496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009565144,0.00001069481,0.001408996,0.00002823173,0.000004168483,0.00004923832,0.00002092561,0.00002077797,0.9975018,0.0000821209,0.00001190564,0.0007656047],"study_design_scores_gemma":[0.00004434479,0.0005411954,0.1971616,0.00001518527,0.00004040085,0.004049638,0.0003673157,0.001153753,0.7917969,0.00042151,0.004382361,0.00002573833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969202,0.0005480609,0.001512099,0.00008729723,0.000007581459,0.00001314852,0.000227193,0.00001826415,0.000666083],"genre_scores_gemma":[0.9968461,0.000329249,0.001388112,0.00008523987,0.000006847384,0.00001333573,0.000747935,0.00001171823,0.0005713009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006922507,"threshold_uncertainty_score":0.002041042,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009693815734392937,"score_gpt":0.195666637954099,"score_spread":0.1859728222197061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}