{"id":"W2070745850","doi":"10.1111/j.1365-2958.2008.06303.x","title":"The PhoQ histidine kinases of <i>Salmonella</i> and <i>Pseudomonas</i> spp. are structurally and functionally different: evidence that pH and antimicrobial peptide sensing contribute to mammalian pathogenesis","year":2008,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Periplasmic space; Biology; Biochemistry; Divalent; Peptide; Antimicrobial peptides; Mutant; Virulence; Peptide sequence; Histidine; Histidine kinase; Microbiology; Escherichia coli; Chemistry; Amino acid; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001225268,0.0003029938,0.0003831454,0.00005543733,0.0002628949,0.0000290658,0.0001725269,0.000322305,0.000002450673],"category_scores_gemma":[0.0001294085,0.0002330834,0.00007364337,0.000072512,0.0007248573,0.000004217642,0.0004743559,0.0001154055,8.781767e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001119378,"about_ca_system_score_gemma":0.00003323716,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003451302,"about_ca_topic_score_gemma":0.0000960738,"domain_scores_codex":[0.9985358,0.0001331504,0.000305467,0.000597523,0.00005644435,0.0003716771],"domain_scores_gemma":[0.9991441,0.00005371083,0.0002345711,0.0003279061,0.0001340999,0.0001055711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000298676,0.00001578339,0.005372309,0.00003419952,0.00006608081,0.00003544785,0.00001722164,0.000003140745,0.9923282,0.00001947485,0.0004177156,0.001391699],"study_design_scores_gemma":[0.0005519488,0.0004011779,0.01551978,0.00005348867,0.00005302464,0.001347507,0.00002544752,0.000002928302,0.9741951,0.00002058971,0.007555612,0.0002734288],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869643,0.01068353,0.0005134099,0.001172923,0.0001788069,0.0002919638,0.000176372,0.0000118999,0.000006817371],"genre_scores_gemma":[0.9937646,0.004582096,0.000794943,0.0005924242,0.00006794504,0.000004562834,0.00008356803,0.00002670106,0.00008317837],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01813318,"threshold_uncertainty_score":0.9504865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009693815734392937,"score_gpt":0.195666637954099,"score_spread":0.1859728222197061,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}