{"id":"W2070768644","doi":"10.1038/nm.3128","title":"GLP-1 receptor activation and Epac2 link atrial natriuretic peptide secretion to control of blood pressure","year":2013,"lang":"en","type":"article","venue":"Nature Medicine","topic":"Diabetes Treatment and Management","field":"Medicine","cited_by":503,"is_retracted":false,"has_abstract":false,"ca_institutions":"University Health Network; University of Guelph; Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"Japan Science and Technology Agency; Canadian Institutes of Health Research; State University of New York Upstate Medical University; Novo Nordisk; Canada Research Chairs; Heart and Stroke Foundation of Canada","keywords":"Atrial natriuretic peptide; Secretion; NPR1; Blood pressure; Internal medicine; NPR2; Receptor; Endocrinology; Medicine; Natriuretic peptide; Heart failure","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002454065,0.000188458,0.0004650491,0.0002204827,0.00003466311,0.000008473166,0.00006544167,0.0002648301,0.0007018049],"category_scores_gemma":[0.0006538279,0.0001294625,0.00006977255,0.0002473893,0.0000742574,0.00009280903,0.00002820804,0.0003270332,0.00002051741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001965822,"about_ca_system_score_gemma":0.00002389848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006812205,"about_ca_topic_score_gemma":0.000002717687,"domain_scores_codex":[0.9987386,0.00004285593,0.000291983,0.000280151,0.0004401295,0.0002062584],"domain_scores_gemma":[0.9990217,0.0001479661,0.000135703,0.0002492435,0.0002531915,0.0001921944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003350233,0.0006420093,0.02457586,0.002256074,0.006585588,0.0000209429,0.002757586,0.00003432697,0.6392964,0.005847706,0.1688691,0.1457642],"study_design_scores_gemma":[0.09701613,0.02057722,0.2036511,0.004944581,0.0279755,0.0000270738,0.0009056072,0.001374634,0.09809632,0.001894441,0.5424193,0.001118126],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9078215,0.01033704,0.0004692246,0.07054338,0.0008939154,0.004443699,0.00001779661,0.0001293925,0.00534403],"genre_scores_gemma":[0.99256,0.0001512305,0.0005835847,0.001722401,0.001527401,0.00004744268,0.00009616766,0.00002148105,0.003290252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5412,"threshold_uncertainty_score":0.7684272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004430149564142866,"score_gpt":0.2382445415718137,"score_spread":0.2338143920076708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}