{"id":"W2070786179","doi":"10.1038/nsmb.1505","title":"Structural elucidation of a PRP8 core domain from the heart of the spliceosome","year":2008,"lang":"en","type":"article","venue":"Nature Structural & Molecular Biology","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Spliceosome; RNA splicing; Ribonucleoprotein; Genetics; RNA; snRNP; Small nuclear ribonucleoprotein; RNase H; RNA-binding protein; Biology; RNase P; Computational biology; Cell biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001192308,0.0001991181,0.0002568533,0.00003144092,0.0001692797,0.000005880476,0.0006371295,0.0004531956,0.00002681578],"category_scores_gemma":[0.0002471027,0.0001080788,0.000231862,0.0002007608,0.0005667471,0.000004619068,0.0002668947,0.0004659223,7.620696e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001366808,"about_ca_system_score_gemma":0.000113735,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002248801,"about_ca_topic_score_gemma":0.00006440226,"domain_scores_codex":[0.9985834,0.0002236426,0.0003006792,0.0003587503,0.0002294414,0.0003040606],"domain_scores_gemma":[0.9988441,0.00003861462,0.0001980143,0.0006817366,0.0001805299,0.00005693718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001284715,0.000003603442,0.0203326,0.000006743873,0.00008002728,0.000002127702,0.00005104801,0.000027993,0.9771502,0.001522804,0.0003861761,0.0003081824],"study_design_scores_gemma":[0.0006076996,0.0002209636,0.1597859,0.00001376938,0.00001779131,0.00008889076,0.00004842591,0.00007881898,0.8345897,0.002940904,0.001452702,0.0001543712],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958448,0.002265713,0.0001449282,0.0009428277,0.0002437529,0.0003443577,0.0001402584,0.000005956086,0.00006743054],"genre_scores_gemma":[0.9978781,0.00002664798,0.0008580868,0.0007192908,0.0001714146,0.000007228049,0.0002544991,0.0000168522,0.00006783734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1425605,"threshold_uncertainty_score":0.4407325,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008472987199480737,"score_gpt":0.2949008355685375,"score_spread":0.2864278483690568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}