{"id":"W2070786506","doi":"10.1097/brs.0b013e31829a6930","title":"Extracellular Signal-Regulated Kinase Inhibition Modulates Rat Annulus Fibrosus Cell Response to Interleukin-1","year":2013,"lang":"en","type":"article","venue":"Spine","topic":"Spine and Intervertebral Disc Pathology","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Air (Canada)","funders":"","keywords":"MAPK/ERK pathway; Aggrecan; Medicine; Downregulation and upregulation; Molecular biology; Kinase; Signal transduction; Cell biology; Biology; Biochemistry; Pathology; Gene; Osteoarthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003092268,0.0006331043,0.0006273041,0.0002655737,0.000198423,0.0002885688,0.0002748519,0.0003421517,0.002483977],"category_scores_gemma":[0.0001395159,0.0001746101,0.0005755594,0.000177094,0.0003417455,0.0001930441,0.0001538167,0.0008944998,0.0006994132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002529848,"about_ca_system_score_gemma":0.0003061955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002261278,"about_ca_topic_score_gemma":0.0004308763,"domain_scores_codex":[0.999737,0.00004417905,0.00002809054,0.00004446496,0.00005309005,0.00009326021],"domain_scores_gemma":[0.9998705,0.00002025421,0.00003841298,0.00001438506,0.00001498678,0.00004142536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002345998,0.0005320022,0.0002419943,0.0001882557,0.00001124213,0.0001343827,0.00002403098,0.00009171501,0.9940885,0.00008001356,0.0001104905,0.002151378],"study_design_scores_gemma":[0.0005338299,0.006167728,0.00591123,0.00002247479,0.00008377973,0.0004157118,0.00008271913,0.0008715565,0.9826739,0.00006624166,0.003158726,0.00001208833],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9915453,0.004265392,0.002004338,0.0002206365,0.0001515058,0.0001064016,0.0003487447,0.00007918279,0.001278538],"genre_scores_gemma":[0.9882838,0.003978476,0.002933921,0.0001220739,0.00008089369,0.0003340133,0.0007617087,0.00001672169,0.003488371],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002483977,"threshold_uncertainty_score":0.008309662,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0107185579856628,"score_gpt":0.2484116745373469,"score_spread":0.2376931165516841,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}