{"id":"W2070790160","doi":"10.1016/j.biomaterials.2010.01.031","title":"PEG–PLA microparticles for encapsulation and delivery of Tat-EGFP to retinal cells","year":2010,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Green fluorescent protein; Biocompatibility; Polyethylene glycol; PEG ratio; Microparticle; In vivo; Gene delivery; Biophysics; Materials science; Polylactic acid; Retinal; Molecular biology; Chemistry; Biochemistry; Transfection; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001612223,0.00008213899,0.0001090393,0.00002925164,0.00003149431,0.00002416797,0.00008030063,0.00008816372,0.00002962692],"category_scores_gemma":[0.00003244025,0.0000752771,0.00003417827,0.00002223232,0.00004519666,0.000003527082,0.00005304886,0.000004901455,0.000008306918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001561987,"about_ca_system_score_gemma":0.0000185086,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003012146,"about_ca_topic_score_gemma":0.00002277147,"domain_scores_codex":[0.999442,0.00001983849,0.0001869192,0.0001862259,0.0000413973,0.000123656],"domain_scores_gemma":[0.9996378,0.000008860971,0.00006472573,0.0001486302,0.00009052474,0.00004947693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002073153,0.00001822661,0.0003359218,0.00002453547,0.00001208748,3.377176e-7,0.00004189546,8.303476e-7,0.9973392,0.00002353868,0.001204623,0.0007915164],"study_design_scores_gemma":[0.0002122682,0.0003063274,0.003677825,0.000009429958,0.00001222797,0.000005278156,0.00002566841,0.000007518723,0.9911432,0.00004451263,0.00446057,0.00009522091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989932,0.00006329966,0.0001961258,0.00005589639,0.0003530058,0.0001984554,0.000112186,0.000005234565,0.00002258587],"genre_scores_gemma":[0.9964113,0.0000256233,0.003175071,0.00007308932,0.0001775245,0.00001856696,0.00004055459,0.000009106399,0.00006914854],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006196019,"threshold_uncertainty_score":0.3069711,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033298714852635,"score_gpt":0.2502296635540396,"score_spread":0.2398966764055132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}