{"id":"W2070790160","doi":"10.1016/j.biomaterials.2010.01.031","title":"PEG–PLA microparticles for encapsulation and delivery of Tat-EGFP to retinal cells","year":2010,"lang":"en","type":"article","venue":"Biomaterials","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Health Canada","keywords":"Green fluorescent protein; Biocompatibility; Polyethylene glycol; PEG ratio; Microparticle; In vivo; Gene delivery; Biophysics; Materials science; Polylactic acid; Retinal; Molecular biology; Chemistry; Biochemistry; Transfection; Biology; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002716773,0.0002472522,0.0001954567,0.0002409158,0.0002296045,0.0002587531,0.0001775798,0.0003749055,0.0004473186],"category_scores_gemma":[0.0001973095,0.0002268668,0.0002413027,0.0001583257,0.0001935436,0.0003330002,0.0001735223,0.0003023911,0.0002238526],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004608435,"about_ca_system_score_gemma":0.0002143056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005710626,"about_ca_topic_score_gemma":0.0009273279,"domain_scores_codex":[0.9998728,0.00001509641,0.00001585895,0.0000283314,0.00004048787,0.00002734595],"domain_scores_gemma":[0.9999056,0.00002801378,0.0000338439,0.000009921633,0.00001093643,0.0000116016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003869074,0.000009328513,0.00002926937,0.00002542856,0.000002913932,0.0000327291,0.00001319114,0.0001038138,0.9986019,0.0001081984,0.00002135785,0.001013301],"study_design_scores_gemma":[0.000004872663,0.00005248483,0.0003476479,0.000001997357,0.000007808192,0.00007144066,0.000003931552,0.0005750045,0.9979468,0.00002144033,0.0009634937,0.000003104575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772009,0.00247026,0.01843128,0.0001382191,0.00005140801,0.00006243322,0.0001520226,0.0001489922,0.001344556],"genre_scores_gemma":[0.9826868,0.0009842948,0.01262425,0.00004564312,0.00001655721,0.00005913077,0.0001369186,0.00004851003,0.003397956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005710626,"threshold_uncertainty_score":0.003343701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033298714852635,"score_gpt":0.2502296635540396,"score_spread":0.2398966764055132,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}