{"id":"W2070804380","doi":"10.1107/s0907444913001182","title":"The structure of cardiac troponin C regulatory domain with bound Cd<sup>2+</sup>reveals a closed conformation and unique ion coordination","year":2013,"lang":"en","type":"article","venue":"Acta Crystallographica Section D Biological Crystallography","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Pentagonal bipyramidal molecular geometry; Troponin C; Crystal structure; Crystallography; Chemistry; Divalent; Stereochemistry; Binding site; Protein structure; Biophysics; Troponin; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009952662,0.000364794,0.0003021646,0.0001181586,0.0002953615,0.0003377451,0.000479932,0.0004863112,0.001974255],"category_scores_gemma":[0.0002228502,0.0001502244,0.0001851918,0.0002375406,0.0003193594,0.0003535053,0.0001520113,0.0007548112,0.0003113193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008747377,"about_ca_system_score_gemma":0.0003569385,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003533681,"about_ca_topic_score_gemma":0.002534519,"domain_scores_codex":[0.9999272,0.000006099593,0.000002920478,0.00002264228,0.00002865016,0.00001254591],"domain_scores_gemma":[0.9998966,0.00001679097,0.00002389078,0.000007164918,0.00002097783,0.00003456512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007653558,0.0001152698,0.002920282,0.0002145402,0.00003802204,0.001331387,0.0001928846,0.002426415,0.978193,0.001274724,0.003162579,0.009365623],"study_design_scores_gemma":[0.000429444,0.001019265,0.1431857,0.0001189046,0.0002029091,0.008725454,0.0004574405,0.05019625,0.7023343,0.00225269,0.09088378,0.0001937499],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851589,0.003546324,0.003530916,0.0005442699,0.0001283684,0.00003624559,0.001479991,0.0001927865,0.005382212],"genre_scores_gemma":[0.9820743,0.001181356,0.006306851,0.0002433621,0.00004039255,0.00001947982,0.006246096,0.00004243284,0.003845748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003533681,"threshold_uncertainty_score":0.007026255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0069496828690809,"score_gpt":0.2093383349601895,"score_spread":0.2023886520911086,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}