{"id":"W2070825008","doi":"10.1002/cncr.10201","title":"Liposome‐encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first‐line therapy of metastatic breast carcinoma","year":2001,"lang":"en","type":"article","venue":"Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":511,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Cardiotoxicity; Doxorubicin; Ejection fraction; Clinical endpoint; Metastatic breast cancer; Internal medicine; Cumulative dose; Heart failure; Breast cancer; Surgery; Randomized controlled trial; Toxicity; Urology; Chemotherapy; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001880462,0.0008981208,0.002265254,0.0003018901,0.0002361362,0.0009018827,0.0007156518,0.001249738,0.003911932],"category_scores_gemma":[0.001701166,0.0004131073,0.0009401826,0.0003211235,0.0008491805,0.0006571093,0.0003590406,0.002011535,0.0005256367],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006765982,"about_ca_system_score_gemma":0.0008168653,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003421592,"about_ca_topic_score_gemma":0.0006555579,"domain_scores_codex":[0.9992425,0.0004684306,0.00005317717,0.0001020275,0.00005422972,0.00007964405],"domain_scores_gemma":[0.9990476,0.0003034006,0.0002334748,0.00006987443,0.0000565051,0.0002892179],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9739435,0.005139766,0.0007305724,0.0003147341,0.0006567034,0.00002788437,0.00003644522,0.0003484469,0.005817179,0.00005255518,0.0002649165,0.01266727],"study_design_scores_gemma":[0.8942152,0.1014681,0.002007935,0.00002177951,0.0004363105,0.00003103266,0.00001366954,0.0004669784,0.0008922248,0.00003928201,0.0003983434,0.000009120357],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951101,0.002398176,0.0002367186,0.0003645634,0.0001781652,0.001038578,0.0001820056,0.00003634801,0.0004552351],"genre_scores_gemma":[0.9943908,0.001473274,0.0005786198,0.0005245177,0.0002552627,0.001563262,0.0003289735,0.00001198992,0.0008734562],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003911932,"threshold_uncertainty_score":0.01308674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904845563698968,"score_gpt":0.3037055696497656,"score_spread":0.274657114012776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}