{"id":"W2070825008","doi":"10.1002/cncr.10201","title":"Liposome‐encapsulated doxorubicin compared with conventional doxorubicin in a randomized multicenter trial as first‐line therapy of metastatic breast carcinoma","year":2001,"lang":"en","type":"article","venue":"Cancer","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":511,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Medicine; Cardiotoxicity; Doxorubicin; Ejection fraction; Clinical endpoint; Metastatic breast cancer; Internal medicine; Cumulative dose; Heart failure; Breast cancer; Surgery; Randomized controlled trial; Toxicity; Urology; Chemotherapy; Oncology; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004288111,0.000256612,0.001251055,0.0002215638,0.00004615707,0.00001376989,0.00008873144,0.00009680905,0.001013726],"category_scores_gemma":[0.00005448673,0.0001886246,0.0003005254,0.0004484558,0.0002159785,0.0001052266,0.0000114677,0.0002253552,0.000008186282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001928405,"about_ca_system_score_gemma":0.0002784753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001214204,"about_ca_topic_score_gemma":0.0003105911,"domain_scores_codex":[0.9980854,0.0001898936,0.0006731621,0.0003320517,0.0004324751,0.0002870217],"domain_scores_gemma":[0.9988788,0.0002110434,0.0002803301,0.0002630331,0.0002415166,0.0001253023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8567337,0.001055184,0.007733763,0.0001057973,0.0007727586,0.00007643182,0.001515416,0.0003477285,0.1286175,0.0000724135,0.00008511297,0.00288419],"study_design_scores_gemma":[0.8459364,0.0005919058,0.008615686,0.0005588754,0.0002348558,0.0001226893,0.0002099948,0.002349803,0.1406844,0.00009654451,0.0003810219,0.0002178562],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936693,0.001316296,0.0002388895,0.001365188,0.0001976653,0.002759487,0.00003405368,0.00003441996,0.0003847532],"genre_scores_gemma":[0.9974817,0.0007703115,0.0001608864,0.0005533922,0.0002237475,0.000314984,0.0001072202,0.00003605175,0.0003517016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01206688,"threshold_uncertainty_score":0.9998995,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02904845563698968,"score_gpt":0.3037055696497656,"score_spread":0.274657114012776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}