{"id":"W2070830789","doi":"10.1023/b:drug.0000011792.13160.b0","title":"Phase I and Pharmacokinetic Study of Fostriecin given as an Intravenous Bolus Daily for Five Consecutive Days","year":2004,"lang":"en","type":"article","venue":"Investigational New Drugs","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre","funders":"University of Toronto","keywords":"Pharmacokinetics; Medicine; Pharmacology; Dosing; Bolus (digestion); Tolerability; Bilirubin; Toxicity; Nausea; Internal medicine; Adverse effect","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009951006,0.001464216,0.002472237,0.0005849213,0.0005499916,0.00101582,0.001220605,0.001373811,0.001891931],"category_scores_gemma":[0.00131334,0.0008076672,0.001009674,0.0006616029,0.001768826,0.001238129,0.0002858323,0.003654608,0.000651497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001359916,"about_ca_system_score_gemma":0.002255528,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002880445,"about_ca_topic_score_gemma":0.003323409,"domain_scores_codex":[0.9993862,0.0002031696,0.00001970394,0.0001406151,0.0000595578,0.0001907444],"domain_scores_gemma":[0.9990305,0.0001773549,0.0001628355,0.000142048,0.00006337796,0.0004240224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7408345,0.0881433,0.003147338,0.0002772811,0.0006560503,0.0003909986,0.0003876375,0.004623393,0.1001325,0.0006934435,0.003893787,0.05681976],"study_design_scores_gemma":[0.1885134,0.7765649,0.01072499,0.00002205666,0.0003152974,0.0004453401,0.0001154803,0.002817221,0.01658993,0.0003455197,0.003485783,0.00006000289],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956234,0.0006217081,0.0008325255,0.0002457386,0.0001119535,0.0008694264,0.0006645145,0.00007896334,0.0009519322],"genre_scores_gemma":[0.9945759,0.0005780992,0.000971687,0.0003012075,0.0001052542,0.0007307393,0.0009424067,0.00003681387,0.001757911],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002880445,"threshold_uncertainty_score":0.009866893,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02067851187441858,"score_gpt":0.3127480514658571,"score_spread":0.2920695395914386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}