{"id":"W2070836963","doi":"10.1021/jm3011178","title":"The Multi-Leu Peptide Inhibitor Discriminates Between PACE4 and Furin And Exhibits Antiproliferative Effects On Prostate Cancer Cells","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Canadian Institutes of Health Research","keywords":"DU145; Furin; Proprotein Convertases; LNCaP; Peptide; Chemistry; Prostate cancer; Cancer research; Cell growth; Biochemistry; Druggability; Cancer cell; Prostate; Cancer; Enzyme; Biology; Internal medicine; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001061858,0.0002918299,0.0002787811,0.0001891975,0.00008949174,0.0001674457,0.0001589012,0.0002273729,0.0008423448],"category_scores_gemma":[0.00009591373,0.0001077045,0.0001687821,0.0001257162,0.00009015032,0.0001332087,0.0001109641,0.0003872331,0.0002298376],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001177346,"about_ca_system_score_gemma":0.0001393191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001921657,"about_ca_topic_score_gemma":0.0003605868,"domain_scores_codex":[0.9999239,0.00001664094,0.000006195782,0.00001451018,0.00002021608,0.00001846391],"domain_scores_gemma":[0.9999378,0.00001708419,0.0000161118,0.000004759298,0.000006362682,0.00001799724],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000210962,0.00006183273,0.0001542784,0.00002574955,0.000005133087,0.00003263917,0.000003737418,0.0001483706,0.996406,0.00002919201,0.00002918249,0.002892899],"study_design_scores_gemma":[0.00004084391,0.001537507,0.001750906,0.000002441351,0.00001166391,0.0003415087,0.000004632901,0.0007349564,0.9943154,0.00001401372,0.001242147,0.000003978604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937258,0.002261799,0.00191081,0.00007054544,0.000026997,0.00004531987,0.0002398674,0.00005739003,0.001661384],"genre_scores_gemma":[0.9941492,0.0009896639,0.002617049,0.00005888195,0.00001443245,0.00002521722,0.0005562733,0.000009873551,0.001579419],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008423448,"threshold_uncertainty_score":0.002817869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01440680761260987,"score_gpt":0.2934821417060922,"score_spread":0.2790753340934823,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}