{"id":"W2070903819","doi":"10.1210/endo.142.10.8528","title":"4-Hydroxytamoxifen Is an Isoform-Specific Inhibitor of Orphan Estrogen-Receptor-Related (ERR) Nuclear Receptors β and γ","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"Nuclear receptor; Estrogen-related receptor gamma; Estrogen-related receptor alpha; Estrogen receptor; Receptor; Neuron-derived orphan receptor 1; Estrogen receptor beta; Estrogen receptor alpha; Orphan receptor; PELP-1; Endocrinology; Selective estrogen receptor modulator; Internal medicine; Estrogen; Nuclear receptor coactivator 1; Biology; Pregnane X receptor; Chemistry; Cell biology; Transcription factor; Biochemistry; Medicine; Cancer; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00008842102,0.0002730504,0.0003085693,0.0001184563,0.0001184052,0.00001542318,0.000239033,0.0004074226,0.0003166804],"category_scores_gemma":[0.00002363612,0.000258137,0.0001193169,0.000167125,0.0003421316,0.00001396975,0.0001683997,0.0002614643,0.0001012523],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001711558,"about_ca_system_score_gemma":0.00003300642,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003229638,"about_ca_topic_score_gemma":0.000002756215,"domain_scores_codex":[0.9983073,0.0001237384,0.000371141,0.0005437227,0.0001205091,0.0005335892],"domain_scores_gemma":[0.9991314,0.00001486797,0.0001476629,0.0004526697,0.00006409218,0.0001892406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003084791,0.0002070806,0.005987136,0.00001356208,0.0002064083,0.00003315678,0.0003480234,0.000007100614,0.9698076,0.00149738,0.006233138,0.01535096],"study_design_scores_gemma":[0.002262739,0.002582483,0.001216768,0.00002223541,0.00004789007,0.0007078459,0.0003300705,0.00006001479,0.6686561,0.0001701131,0.3234425,0.0005012832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935343,0.004276284,0.00001389848,0.0002450584,0.0004762462,0.0002203507,0.00001608434,0.00005204492,0.001165743],"genre_scores_gemma":[0.9934744,0.00498362,0.0004413489,0.0001471953,0.0001983839,0.0000106491,0.0001410921,0.00005801542,0.0005453563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3172094,"threshold_uncertainty_score":0.9999871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008260346547512143,"score_gpt":0.22718306153838,"score_spread":0.2189227149908679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}