{"id":"W2070918681","doi":"10.1139/y09-092","title":"Role of the RhoA/Rho-kinase pathway in the regulation of pulmonary vasoconstrictor function","year":2010,"lang":"en","type":"review","venue":"Canadian Journal of Physiology and Pharmacology","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Research Resources; National Institute of Environmental Health Sciences; National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"RHOA; Rho-associated protein kinase; Myosin-light-chain phosphatase; Kinase; Cell biology; Protein kinase A; Vascular smooth muscle; Calmodulin; Biology; Endocrinology; Internal medicine; Vasodilation; Signal transduction; Calcium; Medicine; Smooth muscle","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005346393,0.0007557797,0.001304543,0.001919655,0.0003128576,0.0008866776,0.0009124533,0.000987847,0.003343037],"category_scores_gemma":[0.0004097826,0.0002340265,0.0003124347,0.001659081,0.0006052101,0.001306041,0.0006069948,0.001574264,0.003951821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007046212,"about_ca_system_score_gemma":0.001042986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008252276,"about_ca_topic_score_gemma":0.001402733,"domain_scores_codex":[0.9998678,0.00001964782,0.00001860523,0.00002549629,0.00005220241,0.00001621502],"domain_scores_gemma":[0.9997819,0.00007359024,0.00002987803,0.000008257014,0.00006346744,0.00004286422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008362974,0.00008948474,0.0001938346,0.007983737,0.00005182611,0.0003998042,0.00005525085,0.0003421236,0.003772146,0.004424045,0.02660648,0.9559976],"study_design_scores_gemma":[0.00002379655,0.0000774338,0.001276461,0.001503123,0.00005139505,0.002083463,0.00005608,0.0001047572,0.0007845375,0.002659735,0.9913623,0.00001693031],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001424493,0.9979336,0.000152837,0.0003106954,0.0001768507,0.000003836463,0.00001095942,0.000007433838,0.001261427],"genre_scores_gemma":[0.0007151616,0.9980988,0.0001838412,0.00009318939,0.0001749505,0.000004799232,0.00001768074,0.000001054517,0.0007106547],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003343037,"threshold_uncertainty_score":0.01118362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01335247281412348,"score_gpt":0.2582542746227083,"score_spread":0.2449018018085848,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}