{"id":"W2070942879","doi":"10.1016/j.jaci.2008.08.008","title":"Genetic or pharmaceutical blockade of p110δ phosphoinositide 3-kinase enhances IgE production","year":2008,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Manitoba","funders":"","keywords":"Immunoglobulin class switching; Cytidine deaminase; Immunoglobulin E; Isotype; Biology; Cytokine; PI3K/AKT/mTOR pathway; Bruton's tyrosine kinase; Signal transduction; Chemistry; Molecular biology; Immunology; Cell biology; Antibody; Tyrosine kinase; B cell; Monoclonal antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003143639,0.000539716,0.0005230787,0.0003954368,0.0002573301,0.0007201078,0.0003684834,0.0006095698,0.002508152],"category_scores_gemma":[0.0002631819,0.0002984782,0.0005622245,0.0002844314,0.0006372595,0.0004255226,0.0003549529,0.00284782,0.0008997078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005350247,"about_ca_system_score_gemma":0.0005627402,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005233423,"about_ca_topic_score_gemma":0.000956155,"domain_scores_codex":[0.9995503,0.0000595036,0.00004052235,0.00005997498,0.0001053513,0.0001843097],"domain_scores_gemma":[0.9997172,0.00007175129,0.00004556455,0.00004231958,0.00001331201,0.0001098234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001048857,0.0003576307,0.0001469681,0.00005284363,0.00001394999,0.00007153562,0.00001289978,0.0002014597,0.99535,0.0002269838,0.0002072551,0.002309432],"study_design_scores_gemma":[0.000192243,0.001107039,0.001678489,0.000007772845,0.00003791654,0.0001510724,0.0000319977,0.001155356,0.9939703,0.0001042297,0.001557786,0.000005791816],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907718,0.001338896,0.002239137,0.0005540957,0.0003577886,0.0000789695,0.0004930269,0.0003353614,0.003830937],"genre_scores_gemma":[0.995104,0.0006517647,0.001243094,0.0001192317,0.00005289524,0.00004813366,0.0004014537,0.0000281412,0.002351386],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002508152,"threshold_uncertainty_score":0.008390665,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03573532481744484,"score_gpt":0.3127536867804398,"score_spread":0.277018361962995,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}