{"id":"W2070956170","doi":"10.1002/eji.200323340","title":"Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections","year":2003,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Sistema Nacional de Investigadores; Canadian Institutes of Health Research; Heubergstiftung; Instituto Mexicano del Seguro Social; Consejo Nacional de Ciencia y Tecnología; Deutsche Forschungsgemeinschaft","keywords":"Biology; Lymphocytic choriomeningitis; Antibody; Virology; Vesicular stomatitis virus; Immunoglobulin light chain; Antibody Repertoire; Immunoglobulin class switching; B cell; Immunoglobulin heavy chain; Virus; Immunoglobulin M; Neutralizing antibody; Immunoglobulin G; Molecular biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004120581,0.0005039701,0.0008745418,0.0006075071,0.001133807,0.00004601414,0.0009666961,0.0003241346,0.0003813011],"category_scores_gemma":[0.001612318,0.0004417044,0.0004024744,0.0005481276,0.0005466695,0.0001786713,0.0007869857,0.001494155,0.001007644],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004059135,"about_ca_system_score_gemma":0.0002970849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006230526,"about_ca_topic_score_gemma":0.000002660889,"domain_scores_codex":[0.9884963,0.008739132,0.001216269,0.0005725689,0.0001198368,0.0008558909],"domain_scores_gemma":[0.9970044,0.0005628905,0.0008752535,0.0007373844,0.0007254551,0.00009457699],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001929595,0.001974255,0.003562287,0.00001484197,0.0005953268,0.0002499149,0.002333639,0.00004845228,0.9865804,0.001957353,0.0003367495,0.0004172201],"study_design_scores_gemma":[0.009648706,0.009713246,0.02419437,0.0001113007,0.0002696099,0.001526829,0.002036883,7.930738e-7,0.7614155,0.0006203403,0.1895338,0.0009286377],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9811552,0.002924261,0.001943062,0.0003946889,0.005857372,0.0006060992,0.00005388407,0.00009121012,0.006974213],"genre_scores_gemma":[0.998639,0.0002432668,0.0001711914,0.0001615901,0.00009356177,0.000007661266,0.00002703576,0.0000519072,0.0006047248],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2251648,"threshold_uncertainty_score":0.9998035,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008591687265803274,"score_gpt":0.2151581913053404,"score_spread":0.2065665040395371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}