{"id":"W2070956170","doi":"10.1002/eji.200323340","title":"Combinatorial immunoglobulin light chain variability creates sufficient B cell diversity to mount protective antibody responses against pathogen infections","year":2003,"lang":"en","type":"article","venue":"European Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique","funders":"Sistema Nacional de Investigadores; Canadian Institutes of Health Research; Heubergstiftung; Instituto Mexicano del Seguro Social; Consejo Nacional de Ciencia y Tecnología; Deutsche Forschungsgemeinschaft","keywords":"Biology; Lymphocytic choriomeningitis; Antibody; Virology; Vesicular stomatitis virus; Immunoglobulin light chain; Antibody Repertoire; Immunoglobulin class switching; B cell; Immunoglobulin heavy chain; Virus; Immunoglobulin M; Neutralizing antibody; Immunoglobulin G; Molecular biology; Immune system; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001738003,0.0003067615,0.0002653783,0.0002889699,0.0001244637,0.0004084327,0.0002281982,0.0002686388,0.000804133],"category_scores_gemma":[0.0002194975,0.0002231156,0.000158738,0.000113542,0.0002751676,0.0002374306,0.0003279543,0.0007155651,0.0002319132],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002044394,"about_ca_system_score_gemma":0.0001526262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001346644,"about_ca_topic_score_gemma":0.0003210837,"domain_scores_codex":[0.9997208,0.00004109588,0.00002068876,0.000048931,0.00005598914,0.0001125003],"domain_scores_gemma":[0.9996368,0.00006972734,0.0001011974,0.00004568332,0.00001805676,0.0001285067],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000850444,0.00003216738,0.0005966119,0.000007074678,0.000003357834,0.00003766965,0.000006960347,0.00008186475,0.9984747,0.00005955202,0.000007167978,0.0006079884],"study_design_scores_gemma":[0.00008110725,0.00131946,0.01648169,0.000009344851,0.00004918339,0.000839412,0.00004743843,0.00257452,0.9775095,0.0001783341,0.0008990144,0.00001099808],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989325,0.00006670443,0.0006039758,0.000007271529,0.000001593003,0.000004729504,0.00002752096,0.000025384,0.0003303667],"genre_scores_gemma":[0.9990061,0.00005311193,0.0006044899,0.00001418473,0.000004931038,0.000007110921,0.00006031316,0.00001404702,0.0002357802],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000804133,"threshold_uncertainty_score":0.002690077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008591687265803274,"score_gpt":0.2151581913053404,"score_spread":0.2065665040395371,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}