{"id":"W2070958052","doi":"10.1016/j.str.2010.05.015","title":"Structural Diversity in Free and Bound States of Intrinsically Disordered Protein Phosphatase 1 Regulators","year":2010,"lang":"en","type":"article","venue":"Structure","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":121,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Basic Energy Sciences; Natural Sciences and Engineering Research Council of Canada; National Science Foundation; Canadian Institutes of Health Research; Office of Science; Brookhaven National Laboratory; U.S. Department of Energy; National Institutes of Health; Brandeis University; Brown University","keywords":"Intrinsically disordered proteins; Folding (DSP implementation); Flexibility (engineering); Function (biology); Phosphatase; Protein folding; Protein phosphatase 1; Protein structure; Protein–protein interaction; Biophysics; Structural bioinformatics; Structural biology; Computational biology; Chemistry; Biology; Cell biology; Biochemistry; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002992198,0.0001647327,0.0004364588,0.0004380569,0.0003369541,0.0006493816,0.0004453037,0.0003183727,0.0008808626],"category_scores_gemma":[0.0005964902,0.0002208097,0.0001943695,0.0002877767,0.0005632752,0.0005342807,0.0002814262,0.0005383152,0.000129449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004206628,"about_ca_system_score_gemma":0.0001391475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005181563,"about_ca_topic_score_gemma":0.0009111293,"domain_scores_codex":[0.999851,0.00003048227,0.00000989486,0.00003960055,0.00004244428,0.00002660623],"domain_scores_gemma":[0.9996254,0.0001536226,0.00007692101,0.00003141647,0.0000400506,0.00007246114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001502744,0.0002308414,0.01521802,0.0001435881,0.0001379715,0.0004775579,0.0006165454,0.01214685,0.9497987,0.00873783,0.0004568301,0.01053249],"study_design_scores_gemma":[0.0003828743,0.001153663,0.1585844,0.00006200276,0.0003860816,0.002481086,0.001577782,0.2800257,0.5216498,0.02649682,0.006881139,0.0003185125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998207,0.0002965149,0.001046515,0.00003535097,0.000003587985,0.00000164646,0.00003270484,0.00002906388,0.0003477168],"genre_scores_gemma":[0.999545,0.00005362458,0.0002059583,0.00001396109,0.000002852518,0.000001751345,0.00005763308,0.000006266195,0.000113009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008808626,"threshold_uncertainty_score":0.003052115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.002805057409384419,"score_gpt":0.2011579225777496,"score_spread":0.1983528651683652,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}