{"id":"W2070979982","doi":"10.1038/ja.2010.13","title":"Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1","year":2010,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Streptomyces coelicolor; Secondary metabolism; Secondary metabolite; Streptomyces; Antimicrobial; Biology; Actinorhodin; Streptomycetaceae; Antibiotics; Heterologous; Gene; Microbiology; Actinomycetales; Bacteria; Computational biology; Genetics; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002533126,0.0007477782,0.0004250524,0.0004080054,0.0001833419,0.0006115481,0.000252603,0.0002584976,0.000553429],"category_scores_gemma":[0.0002950345,0.0001705085,0.0003161513,0.0003599454,0.0004178964,0.0001889997,0.0004873512,0.00102881,0.0003065603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000452332,"about_ca_system_score_gemma":0.0002972214,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007646361,"about_ca_topic_score_gemma":0.0009833659,"domain_scores_codex":[0.9996082,0.00007464168,0.0000447747,0.00005333745,0.0001444605,0.00007459109],"domain_scores_gemma":[0.9996893,0.00007706236,0.00008337841,0.0000451001,0.00002759397,0.00007742138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000073499,0.00003395079,0.0001706411,0.00001392595,0.000002325646,0.00002711417,0.00001150344,0.00006605514,0.9989986,0.00006934538,0.00001075756,0.0005222221],"study_design_scores_gemma":[0.00001486294,0.0001343832,0.002009011,0.000002893942,0.000007844548,0.00009333822,0.00002705258,0.0008287771,0.9963397,0.00003021323,0.0005071012,0.000004868998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964367,0.0003978504,0.001772189,0.00008109443,0.0000286069,0.00001652745,0.0002234754,0.0001005283,0.000943024],"genre_scores_gemma":[0.9966968,0.0001735994,0.001477278,0.0000220787,0.000007492868,0.00001331306,0.0004642467,0.00003019226,0.001114941],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007646361,"threshold_uncertainty_score":0.003281832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559000267639873,"score_gpt":0.2565839075645215,"score_spread":0.2409939048881228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}