{"id":"W2070979982","doi":"10.1038/ja.2010.13","title":"Induction of antimicrobial activities in heterologous streptomycetes using alleles of the Streptomyces coelicolor gene absA1","year":2010,"lang":"en","type":"article","venue":"The Journal of Antibiotics","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Streptomyces coelicolor; Secondary metabolism; Secondary metabolite; Streptomyces; Antimicrobial; Biology; Actinorhodin; Streptomycetaceae; Antibiotics; Heterologous; Gene; Microbiology; Actinomycetales; Bacteria; Computational biology; Genetics; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005819895,0.000116647,0.0003795324,0.0001285161,0.00005531621,0.000008676276,0.0002256802,0.0001258024,0.00002475505],"category_scores_gemma":[0.0002025418,0.00005730077,0.0001352757,0.0001941358,0.0003723739,0.00008836901,0.00006606124,0.0005162731,2.207448e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001931026,"about_ca_system_score_gemma":0.0001207631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007927194,"about_ca_topic_score_gemma":0.00006253675,"domain_scores_codex":[0.9989557,0.000097103,0.0005224823,0.00007763489,0.0002014381,0.0001456801],"domain_scores_gemma":[0.9986584,0.0001109456,0.0007705218,0.0002322179,0.0002006538,0.00002729885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000325652,0.0001670601,0.01625844,0.00007724453,0.00008728649,0.000003179553,0.0003003227,0.00007929209,0.9814181,0.000006189431,0.0001023895,0.001174814],"study_design_scores_gemma":[0.0004396626,0.0002080177,0.02744337,0.0001938647,0.0001762761,0.0004244791,0.0002959672,0.00005040477,0.9706485,0.00001452663,0.00005038846,0.00005456887],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998248,0.0001247501,0.00000416964,0.0009178283,0.0005223054,0.0001507324,0.00001373093,0.000002869452,0.00001559549],"genre_scores_gemma":[0.9982059,0.000212435,0.001208839,0.00006567517,0.0002786627,8.896607e-10,6.624724e-7,0.00001084318,0.00001700687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01118492,"threshold_uncertainty_score":0.2336658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01559000267639873,"score_gpt":0.2565839075645215,"score_spread":0.2409939048881228,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}