{"id":"W2070989278","doi":"10.1038/nature12402","title":"The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein","year":2013,"lang":"en","type":"article","venue":"Nature","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":209,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"","keywords":"Neurotoxicity; Neurodegeneration; Scrapie; Cell biology; Calpain; Biology; Toxicity; Biochemistry; Chemistry; Molecular biology; Prion protein; Enzyme; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002104877,0.0004039153,0.0002216468,0.0002876702,0.000195861,0.0002591632,0.000242626,0.0004061307,0.0005678461],"category_scores_gemma":[0.000225406,0.0001602931,0.0002120753,0.000118084,0.0004167429,0.0003191853,0.0002059236,0.0004694264,0.0002298893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002539837,"about_ca_system_score_gemma":0.0001380803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002754695,"about_ca_topic_score_gemma":0.000327037,"domain_scores_codex":[0.9998294,0.00004292509,0.000008806694,0.00002032854,0.00006802383,0.00003043531],"domain_scores_gemma":[0.9998286,0.00004368302,0.0000462313,0.00002471162,0.00002853285,0.00002830292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009002411,0.00001312364,0.0003093987,0.00002939031,0.000008394182,0.0002677878,0.00001096068,0.00008567881,0.9971578,0.000263359,0.00005585115,0.001708222],"study_design_scores_gemma":[0.00002315723,0.0004194631,0.01165327,0.000009191671,0.00002184106,0.002421499,0.00001945721,0.001486632,0.9821118,0.0005990262,0.00122453,0.000009985099],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902331,0.002894622,0.004024627,0.0001791128,0.00003389359,0.00001740592,0.00006199615,0.00008810354,0.002467312],"genre_scores_gemma":[0.9975556,0.0008161509,0.0008034008,0.00007917319,0.00001433459,0.000004621477,0.00006685573,0.000008184545,0.0006515289],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005678461,"threshold_uncertainty_score":0.00189966,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00412625331982384,"score_gpt":0.2344155703852321,"score_spread":0.2302893170654083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}